PET-imaging of Unruptured Intracranial Aneurysm Inflammation

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Turku University Hospital
Updated on 26 November 2022

Summary

The main purpose of this study is to determine if PET-imaging can be used to evaluate inflammation level of intracranial aneurysms, thus helping to evaluate the rupture risk of intracranial aneurysm.

Description

Study subjects are patients who are diagnosed with an unruptured saccular intracranial aneurysm and planned for elective surgical treatment of intracranial aneurysms. Prior the planned surgery, all study subjects will undergo PET-imaging of the brain with 18F-FDG- and 68Ga-DOTANOC-tracers targeting glucose metabolism and somatostatin receptors in inflammatory cells. After PET-imaging, samples for histopathological examination from the intracranial aneurysm sac will be collected during the surgery from every study subject. Blood samples are collected prior to aneurysm operation from the routine pre-operative laboratory tests. Cerebrospinal fluid samples are collected during the surgical procedure from the surgical site. From blood samples we will evaluate expression of 20 different circulating microRNAs (miRNA) and the level of tumor necrosis factor-1, interleukin 1 beta, vascular endothelial growth factor, and evaluate correlations between miRNA expression and SUVmax in PET-imaging and miRNA and aneurysm histological findings.

Correlation between inflammatory findings in histological studies and PET-imaging will be evaluated (correlation of SUVmax to aneurysm histological findings).

Details
Condition Inflammation, Inflammation, Berry Aneurysm, Aneurysm, Aneurysm, cerebral aneurysm, intracranial aneurysm, cerebral aneurysms
Treatment PET imaging, 18F-FDG, PET imaging, 68Ga-DOTANOC
Clinical Study IdentifierNCT04715503
SponsorTurku University Hospital
Last Modified on26 November 2022

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