Acute Heart Failure With Reduced Ejection Fraction - COngestion Discharge Evaluation

  • STATUS
    Recruiting
  • End date
    Aug 21, 2026
  • participants needed
    200
  • sponsor
    Central Hospital, Nancy, France
Updated on 30 January 2021

Summary

The AHF-CODE reduced study is a prospective, non-randomized, monocenter study performed in patients with heart failure with reduced ejection fraction admitted for worsening heart failure.

The main objective of the AHF-CODE study is to identify congestion markers (clinical, biological and ultrasound) at the end of hospitalization for acute heart failure that are associated with the risk of all cause death or rehospitalization for acute heart failure within 3 months of hospital discharge.

Details
Condition Acute Heart Failure
Treatment Telephone interview, Clinical examination centered on congestion, Cardio-pulmonary, peritoneal, , jugular and renal venous Doppler ultrasounds, Biological: Blood sample retrieved for biological assessment and biobanking
Clinical Study IdentifierNCT04343443
SponsorCentral Hospital, Nancy, France
Last Modified on30 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients hospitalised for acute heart failure
Patients with reduced ejection fraction (Ejection Fraction <40%) or (40% Ejection Fraction < 50)
Patients considered clinically discharging from hospitalisation for acute heart failure
Age 18 years
Patients having received complete information regarding the study design and having signed their informed consent form
Patient affiliated to or beneficiary of a social security scheme

Exclusion Criteria

Comorbidity for which the life expectancy is 3 months
Dialysis patient (peritoneal dialysis or hemodialysis) or patients with glomerular filtration rate <15 ml/min/m2 at inclusion
History of lobectomy or pneumonectomy lung surgery
Severe pulmonary or pleural pathology preventing reliable acquisition of lung ultrasound images: severe emphysema, chronic pleurisy, pulmonary fibrosis, etc
Valvulopathy causing decompensation of heart failure for which intervention is being considered
Pregnant woman, parturient or nursing mother
Adult person subject to a legal protection measure (guardianship, curatorship, safeguard of justice) Adult person who is unable to give consent
Person deprived of liberty by a judicial or administrative decision
Person subject to psychiatric care pursuant to Articles L. 3212-1 and L. 3213-1 of the Public Health Code
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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