Diagnosing Intensive Care Unit (ICU) Acquired Weakness

  • STATUS
    Recruiting
  • days left to enroll
    84
  • participants needed
    150
  • sponsor
    Emory University
Updated on 26 February 2021

Summary

The goal of this study is to develop a non-invasive test to diagnose intensive care unit (ICU) acquired weakness that can be administered to both responsive and non-responsive patients. Study participation will involve the measurement of muscle fatigue during a single 30 minute session. Skeletal muscle will be stimulated with an FDA approved clinical electrical stimulator and accelerations will be passively recorded with an accelerometer.

Description

The primary purpose of this study is to develop a procedure to identify intensive care unit (ICU) acquired weakness. This condition occurs in a subset of people admitted into the ICU, and is associated with a 30% increased risk of death before discharge from the ICU. There are currently major limitations in the ability to diagnose ICU acquired weakness, making it difficult to study. The goal is to develop a non-invasive test that can be administered to both responsive and non-responsive patients. The current proposal will focus on replicating the results of previous research using motion detecting accelerometers to measure fatigue in human skeletal muscles. This study is designed to test out the procedures in patients who have been transferred from the ICU to a lower level of care so that follow-on studies can be designed to help mitigate this condition in the ICU.

Details
Condition ICU Acquired Weakness
Treatment Clinical Electrical Stimulator
Clinical Study IdentifierNCT04166630
SponsorEmory University
Last Modified on26 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients transferred from the ICU to a lower level of care within the past 7 days
Mechanical ventilation for greater than 7 days while in the ICU
Ability to understand English and provide written consent

Exclusion Criteria

Vulnerable populations including: patients who are pregnant or prisoners
Patients who are unable to understand English or provide written consent
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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