Effects of Left Atrial Appendage Resection and Marshall Ligament Amputation on Clinical Outcome in Patients Undergoing Off-pump Coronary Artery Bypass

  • End date
    Dec 31, 2026
  • participants needed
  • sponsor
    China National Center for Cardiovascular Diseases
Updated on 30 January 2021


Surgical occlusion of the left atrial appendage (LAAO) is sometimes performed during the cardiac surgery to reduce long-term risk of stroke.A previous study found that LAAO may be associated with increased risk of postoperative atrial fibrillation.New-onset atrial fibrillation (NOAF) after coronary artery bypass graft is related to an increased short-term and long term risk of stroke and mortality.Marshall ligament amputation may reduce the occurence of atrial fibrillation. However, little is known whether this approach is justified during the coronary artery bypass graft.Therefore, this study aimed to investigate whether LAAO and Marshall ligament amputation during off-pump coronary artery bypass was associated with reduced risks of postoperative new-onset atrial fibrillation and stroke.

Condition Arrhythmia, Coronary Artery Disease, Coronary heart disease, Atrial Fibrillation, Cerebrovascular accident, Atrial Fibrillation (Pediatric), Stroke, Cardiac Ischemia, Dysrhythmia, Myocardial Ischemia, cerebrovascular accidents, strokes, cerebral
Treatment Left Atrial Appendage Resection and Marshall Ligament Amputation
Clinical Study IdentifierNCT04220047
SponsorChina National Center for Cardiovascular Diseases
Last Modified on30 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 80 yrs?
Gender: Male or Female
Do you have any of these conditions: Atrial Fibrillation (Pediatric) or Atrial Fibrillation or Stroke or Cardiac Ischemia or cerebrovascular accidents or strokes, cerebral or Coronary hea...?
isolated first off-pump coronary artery bypass

Exclusion Criteria

Preoperative atrial fibrillation or a history of atrial fibrillation
Concurrent cardiac or non-cardiac surgery
Intraoperative convert to bypass bypass surgery
Emergency surgery
History of previous cardiac surgery
Severe organ dysfunction
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