Effectiveness and Safety of Dabrafenib in Combination With Trametinib as Adjuvant Treatment for Chinese Patients With Stage III BRAF V600 Mutation-positive Melanoma After Complete Resection

  • End date
    Dec 31, 2026
  • participants needed
  • sponsor
    Novartis Pharmaceuticals
Updated on 23 October 2022
braf v600 mutation
immunologic adjuvant


This is a prospective, open label, single-arm, multicenter, non-interventional study of dabrafenib in combination with trametinib as adjuvant treatment for Chinese patients with stage III BRAF V600 mutation positive melanoma after complete resection.


The study will consist of a treatment phase and follow-up phase. The treatment period is 12 months. Discontinuation of study treatment may occur earlier than 12 months for disease recurrence, death, unacceptable toxicity or withdrawal of consent. Patients will be followed for disease recurrence every 6 months and up to 24 months after the end of treatment (EOT)

Condition Melanoma
Treatment Dabrafenib, Trametinib
Clinical Study IdentifierNCT04666272
SponsorNovartis Pharmaceuticals
Last Modified on23 October 2022


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