Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI

  • STATUS
    Recruiting
  • days left to enroll
    32
  • participants needed
    50
  • sponsor
    Damascus University
Updated on 28 January 2021

Summary

Selection of developmentally competent oocytes enhances IVF efficiency. Usually, oocyte quality is determined based on its nuclear maturation and the presence of specific cytoplasmic and extracytoplasmic morphologic features. Gonadotropin-releasing hormone agonists (GnRH Agonists) and gonadotropin-releasing hormone antagonists (GnRH Antagonists) are used during controlled ovarian stimulation (COS) protocols in order to prevent premature luteinizing hormone (LH) surge and premature ovulation. However, GnRH receptors are also expressed in extra-pituitary tissues such as ovary, but it is still unknown whether the type of GnRH analogues used during COS could affect the oocyte morphology, especially with the limited and conflicted currently available data. Thus, we are conducting this prospective, non-randomised, open-label, clinical trial to compare the effects of two pituitary suppression regimens; GnRH Agonist-Long Protocol and GnRH Antagonist-Flexible Protocol on oocyte morphology during IVF/ICSI.

Details
Condition Intracytoplasmic sperm injection, Female Genital Diseases, Infertility, In Vitro Fertilization, Gynecological Infections, icsi, sterility, unable to conceive
Treatment Triptorelin acetate, Cetrorelix, Human Chorionic Gonadotropin (hCG), recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin
Clinical Study IdentifierNCT04724486
SponsorDamascus University
Last Modified on28 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Women undergoing IVF/ICSI
Age: 18-39 years
Both ovaries present

Exclusion Criteria

Age 40 years
History of three or more previous IVF failures
Patients with hormonal disorders like hyperprolactinemia, thyroid disorders
Patients with Polycystic Ovarian Syndrome
Patients who previously undergo Unilateral Oophorectomy
Patients with chronic diseases: diabetes mellitus, cardiovascular diseases, liver diseases, kidney diseases
Patients with diseases may affect IVF outcomes: Endometriosis, uterine fibroids, Hydrosalpinx, Adenomyosis, autoimmune diseases
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