Is Clonal Hematopoiesis of Indeterminate Potential Associated With Unprovoked Pulmonary Embolism?

  • STATUS
    Recruiting
  • End date
    Jan 4, 2023
  • participants needed
    544
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 4 February 2021

Summary

The clonal hematopoiesis of indetermined prognosis (CHIP) has been described as risk factor for juvenile atherosclerosis. Moreover, some of CHIP genes are responsible of myeloproliferative disorders. Venous thrombosis are frequent in these disorders. The purpose of this project is to determine if CHIP is frequent in unprovoked pulmonary embolism and could be part of the pathophysiology.

Details
Condition Pulmonary Disease, Pulmonary Embolism, Hematopoiesis, Lung Disease, lung embolism
Treatment Blood sample
Clinical Study IdentifierNCT04711746
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on4 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 65 yrs?
Gender: Male or Female
Do you have any of these conditions: Hematopoiesis or Pulmonary Disease or lung embolism or Pulmonary Embolism or Lung Disease?
Do you have any of these conditions: Pulmonary Embolism or Lung Disease or lung embolism or Hematopoiesis or Pulmonary Disease?
For cases : Previous proximal unprovoked pulmonary embolism, negative thrombophilia screening
For control : Previous proximal provoked pulmonary embolism, negative thrombophilia screening

Exclusion Criteria

Age superior to 65 years old
Active cancer
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