Physiology and Structure of the Small Airways in Patients With Chronic Airflow Obstruction or COVID-19

  • End date
    Feb 2, 2022
  • participants needed
  • sponsor
    Imperial College London
Updated on 28 January 2021


The purpose of this research project is to study small airways physiological function in patients with chronic obstructive lung disease or COVID-19 and explore the relationship with in-vivo microanatomical small airway structure as measured by OCT. Correlating endobronchial assessment with multiple breath nitrogen washout and impulse oscillometry will allow the characterisation of the relationship between small airway structural findings and these validated investigations. A small volume lung wash, endobronchial brushings and the collection of a limited number of endobronchial cryobiopsy samples will be performed to better understand the endobronchial environment of the small airways through inflammatory studies. Following the completion of any such work, residual samples will be stored in a "bio-bank" to enable the completion of future work. Understanding the relationship with symptom-based quality of life scoring questionnaires and a functional assessment of exercise capacity will help elucidate the clinical impact of in-vivo small airways findings.

Condition Chronic Obstructive Lung Disease, Asthma, Allergies & Asthma, COPD (Chronic Obstructive Pulmonary Disease), Asthma (Pediatric), Reactive Airway Disease, *COVID-19, Covid-19, chronic obstructive pulmonary disease, asthmatic, bronchial asthma, COPD, chronic obstructive pulmonary disease (copd), Small Airways Disease
Clinical Study IdentifierNCT04716023
SponsorImperial College London
Last Modified on28 January 2021


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Inclusion Criteria

Is your age greater than or equal to 16 yrs?
Gender: Male or Female
Do you have any of these conditions: chronic obstructive pulmonary disease (copd) or chronic obstructive pulmonary disease or Covid-19 or Reactive Airway Disease or *COVID-19 or bronchial...?
Age 16 or over
Scheduled for bronchoscopy as part of clinical care or research protocol
No bleeding diathesis or therapeutic anticoagulation
FEV1/FVC ratio <70% or
Diagnosed by standard clinical methods
Post-bronchodilator FEV1 60% predicted or COVID-19 infection or previous COVID-19 infection (confirmed as per local guidelines)

Exclusion Criteria

Unable to provide informed consent
Exacerbation of obstructive airways disease or respiratory infection requiring systemic antibiotics or corticosteroids in the 6 weeks prior to enrolment unless suffering from COVID-19 infection and bronchoscopy is required for clinical reasons
Contra-indications to performing lung function testing
Aortic aneurysm >6cm
Unstable cardiovascular disease (unstable angina, myocardial infarction or pulmonary embolism <4 weeks prior)
Severe aortic stenosis
Cerebral aneurysm
Thoracic or abdominal surgery <4 weeks prior
Contra-indications to passing oesophageal balloons
Oesophageal ulceration or varices
Sinusitis, recent nasal surgery or epistaxis
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