PRecision Oncology CUhk pRogrammE (PRO-CURE)

  • End date
    Dec 31, 2024
  • participants needed
  • sponsor
    Brigette Ma
Updated on 16 May 2021


The main aim of this project is to establish an innovative model of a comprehensive precision oncology platform to help individualizing drug therapy for patients with advanced cancers at The Chinese University of Hong Kong. The other objectives include to optimize the genomic matching and access of patients with unique cancer subtypes to the relevant clinical trials of novel therapies, and to construct a personalized drug screening platform for individuals using novel cancer models established from patient-derived cancer cells and tissues. Other objectives include to investigate the utility and feasibility of genomic sequencing using circulating tumor DNA(ctDNA), and to establish a biobank of tumor tissues derived from patients with unique cancer subtypes.

Condition Gastrointestinal Neoplasm, gastrointestinal cancer, gastrointestinal cancers
Treatment NGS, PDO/PDX establishment
Clinical Study IdentifierNCT04724070
SponsorBrigette Ma
Last Modified on16 May 2021


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Inclusion Criteria

Must be aged between 18 to 75 years
Must have ECOG performance status of 0 to 1
Must have histologically/cytologically confirmed cancers of certain subtype
Medically fit patients who would need systemic therapy as part of their oncological treatment in any one or more of the following oncological setting(s): palliative, neoadjuvant, adjuvant, concurrent with radiotherapy. This includes patients who have limited systemic therapeutic options for their cancers and are candidates for clinical trials
Able to give written informed consent
Willing to have blood samples taken
Availability of an archived paraffin-embedded tumor block

Exclusion Criteria

Patients who refuse or are medically unfit for systemic therapy for their cancer
Patients with more than one invasive cancers diagnosed over the last FIVE years
Patients without measurable tumor lesions on radiological imaging
Patients who are unable to give written informed consent
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How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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