HepTcell Immunotherapy in Patients With Inactive Chronic Hepatitis B (CHB)

  • End date
    Jul 14, 2023
  • participants needed
  • sponsor
    Altimmune, Inc.
Updated on 7 October 2022


A study to evaluate the antiviral effects, immunogenicity, and safety of HepTcell in treatment-naive patients with inactive Chronic Hepatitis B (CHB) and low Hepatitis B surface antigen (HBsAg) levels.

Condition Hepatitis B, Chronic
Treatment Placebo, HepTcell
Clinical Study IdentifierNCT04684914
SponsorAltimmune, Inc.
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Men and women 18 to 65 years of age, inclusive
Inactive CHB with documented HBsAg positivity for at least 12 months before Day 1
qHBsAg ≥ 10 IU/mL but ≤ 100 IU/mL in the 12 months prior to screening
HBV DNA ≥ 10 IU/mL at screening
AST, ALT, INR, albumin, total bilirubin (excluding patients with Gilbert Syndrome) and direct bilirubin within normal limits at screening

Exclusion Criteria

Positive hepatitis B e antigen (HBeAg) at screening
History of a hepatitis B flare or 1-log increase in HBV DNA or HBsAg in the prior 12 months
Undetectable HBV DNA at screening
Fibroscan > 8.5 kPA at screening, or history of hepatic fibrosis or cirrhosis (NB, a Fibroscan is not required if an examination is performed within 12 months or a liver biopsy was performed within 2 years before Screening and no fibrosis [F1 or greater] was identified)
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer  to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note