Effect of Bariatric Surgery on Brain Insulin Sensitivity

  • End date
    Oct 26, 2023
  • participants needed
  • sponsor
    University Hospital Tuebingen
Updated on 26 January 2021


Adiposity is associated with prediabetes and type 2 diabetes. In very severe cases of adiposity in combination with type 2 diabetes, bariatric surgery has proven to be a successful therapy option. So far the molecular mechanisms that lead to an improvement of type 2 diabetes after bariatric surgery are not fully understood. It is planned to characterize the metabolic and neuroendocrine changes in subjects before and after bariatric surgery. One special focus of the study is brain insulin resistance, a condition known to be associated with obesity with impact on the brain and whole body metabolism.

Condition adiposity, Obesity
Treatment Bariatric Surgery
Clinical Study IdentifierNCT03705923
SponsorUniversity Hospital Tuebingen
Last Modified on26 January 2021


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Inclusion Criteria

Is your age between 18 yrs and 75 yrs?
Gender: Male or Female
Do you have any of these conditions: adiposity or Obesity?
age between 18 and 75 years
planned bariatric surgery (laparoscopic Roux-en-Y gastric bypass or laparoscopic sleeve gastrectomy)
stable medication 10 weeks before begin of the study

Exclusion Criteria

persons who wear non-removable metal parts in or on the body
persons with reduced temperature sensitivity and / or increased sensitivity to heating of the body
cardiovascular disease can not be ruled out, e.g. manifest coronary heart disease, heart failure greater than NYHA 2, previous heart attack, stroke condition
persons with hearing impairment or increased sensitivity to loud noises
people with claustrophobia
minors or non-consenting subjects are also excluded
subjects with an operation less than 3 months
neurological and psychiatric disorders
subjects with hemoglobin Hb <11 g / dl
hypersensitivity to any of the substances used
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