Isolating & Exploiting the Mechanisms That Link Breakfast to Human Health - Acute

  • STATUS
    Recruiting
  • End date
    May 1, 2022
  • participants needed
    15
  • sponsor
    University of Bath
Updated on 26 January 2021

Summary

Following the establishment of causal links between breakfast consumption, the individual components of energy balance, and health it is now important to examine and target the underlying biological mechanisms involved to maximise potential health benefits.

To begin investigating the outlined mechanisms healthy, non-obese participants will be recruited to take part in phase I (acute crossover design) of a wider project.

Description

Causal links between breakfast consumption, the individual components of energy balance, and health have recently been established and it is now important to examine and target the underlying biological mechanisms involved to maximised potential health benefits.

Specifically, the substitution of a portion of carbohydrate for protein at breakfast may enhance the potential health benefits of breakfast through targeting distinct mechanistic pathways. Broadly, introducing a greater protein load at breakfast increases insulin secretion and delays gastric emptying, thereby eliciting a potentiated insulin response. In turn this may therefore improve glucose tolerance during a subsequent meal. Additionally, maintenance of euglycaemia following breakfast consumption, coupled with the thermic effect of feeding protein may accentuate the elevated energy expenditure following breakfast observed in previous studies. Finally, both the physical and chemical properties of protein exert a marked satiating effect. Collectively, these mechanisms could interact to maximise the net impact of breakfast on energy balance and associated health outcomes. However, whilst the evidence indicates obvious benefits of feeding a higher protein dose at breakfast, relatively little research has focused on the response to protein over multiple meals/days. Furthermore, and importantly, the mechanisms involved in the second-meal phenomenon and the potential for initial meals of varied composition to target these mechanisms have never been systematically investigated.

To begin investigating the outlined mechanisms healthy, non-obese participants will be recruited to take part a randomised crossover trial that will contrast the acute metabolic responses to a protein-enriched breakfast, with a carbohydrate rich breakfast, and the total omission of breakfast.

Details
Condition Appetite, Postprandial Metabolism
Treatment Carbohydrate Rich Breakfast, Whey protein enriched breakfast
Clinical Study IdentifierNCT03866720
SponsorUniversity of Bath
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 65 yrs?
Gender: Male or Female
Do you have any of these conditions: Postprandial Metabolism or Appetite?
Body mass index 18.5-29.9 kgm-2
Age 18-65 years
Able and willing to provide informed consent and safely comply with study procedures
Females to maintain record of regular menstrual cycle phase or contraceptive use
No anticipated changes in diet/physical activity during the study (e.g. holidays or diet plans)
Inclusive to all breakfast habits (e.g. regular skipper / consumer)

Exclusion Criteria

Any reported condition or behaviour deemed either to pose undue personal risk to the participant or introduce bias
Any diagnosed metabolic disease (e.g. type 1 or type 2 diabetes)
Any reported use of substances which may pose undue personal risk to the participants or introduce bias into the experiment (e.g. smoking/substance abuse)
Lifestyle not conforming to standard sleep-wake cycle (e.g. shift worker)
Any reported recent (<6 months) change in body mass ( 3%)
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