Individualizing Anti-Inflammatory Medications for Adults With Axial Spondyloarthritis: A Series of N-of 1 Trials

  • STATUS
    Recruiting
  • End date
    Jul 1, 2023
  • participants needed
    75
  • sponsor
    The University of Texas Health Science Center, Houston
Updated on 8 March 2022

Summary

The purpose of this study is to compare selective cyclooxygenase-2 (COX-2) and non selective COX inhibitors with respect to the extent to which disease activity is improved without self reported, unacceptable side effects among individual patients with axial spondyloarthritis (AxSpA),to compare selective COX-2 and nonselective COX inhibitors impact on Health related Quality of Life (HrQOL) and how this relates to changes in disease activity and to conduct proteomic assessment of predictive biomarkers of non steroidal anti-inflammatory drug(NSAID) response

Details
Condition Axial Spondyloarthritis
Treatment Drug order 1, Drug order 2, Drug order 3, Drug order 4, Drug order 5, Drug order 6
Clinical Study IdentifierNCT04115098
SponsorThe University of Texas Health Science Center, Houston
Last Modified on8 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients must meet modified New York Classification and/or Assessment of Spondyloarthritis International Society (ASAS) criteria for Classification Criteria for AxSpA
Ankylosing Spondylitis Disease Activity Score greater than or equal to 2.1

Exclusion Criteria

Changing background biologic/disease modifying-rheumatic medications within less than 3 months
Opioid medication use
Current or expected pregnancy
History of cardiovascular disease (previous stroke, myocardial infarction, or percutaneous intervention
End stage liver disease
Chronic Kidney Disease greater than Stage IIIb
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