Impact of High Protein and Low Carbohydrate Smoothie Drinks in Type-2 Diabetes Mellitus

  • STATUS
    Recruiting
  • End date
    Sep 30, 2021
  • participants needed
    60
  • sponsor
    Mahidol University
Updated on 26 January 2021

Summary

We compared between a regular high protein or a high protein and low carbohydrate smoothie drinks with conventional diabetic enteral drinks (Glucerna) on glucose homeostasis, insulin and lipid metabolism in type 2 diabetic and obese individuals.

Description

We aimed to determine the effect of high protein and low carbohydrate smoothie drinks on glucose homeostasis, insulin and lipid metabolism in type 2 diabetic and obese individuals. We compared between a regular high protein or a high protein and low carbohydrate smoothie drinks with conventional diabetic enteral drinks (Glucerna). A crossover design study was done in 60 diabetic participants. Participants consumed 300 kilocalories of each drink at a time with one week wash out period between drinks and glucose response curves at baseline, 30, 60, 90, 120, 180 and 240 minutes were monitored and compared. The products were formulated to supply 1 kilocalorie/milliliter (kcal/ml). Dietary compositions in regular formulas (smoothie, SM) were 30-40% carbohydrate, 20-30% protein and 30-50% fat. While in smoothie with low carbohydrate formulas (SMLS), they were 25-35% carbohydrate, 25-30% protein and 35-55% fat vs. a control formula (Glucerna).

Details
Condition NIDDM, Diabetes Mellitus, Type 2, Diabetes Mellitus Type 2, type 2 diabetes mellitus, type 2 diabetes, type ii diabetes, noninsulin-dependent diabetes mellitus, diabetes type 2
Treatment smoothie with regular formulas (SM), smoothie with low carbohydrate formulas (SMLS), conventional diabetic enteral drinks (Glucerna)
Clinical Study IdentifierNCT04577274
SponsorMahidol University
Last Modified on26 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Is your age between 18 yrs and 65 yrs?
Gender: Male or Female
Do you have any of these conditions: type 2 diabetes mellitus or Diabetes Mellitus, Type 2 or Diabetes Mellitus Type 2 or type 2 diabetes or noninsulin-dependent diabetes mellitus or type...?
Do you have any of these conditions: diabetes type 2 or noninsulin-dependent diabetes mellitus or Diabetes Mellitus Type 2 or type 2 diabetes or type 2 diabetes mellitus or type ii diabet...?
people with type 2 diabetes mellitus or use blood glucose-lowering drugs more than 3 months
BMI > 25 kg/m^2
HbA1c 6.5 - 8.5
use stable level of blood glucose-lowering drugs and blood lipid-lowering drugs more than 3 months

Exclusion Criteria

pregnancy or breastfeeding
people with chronic diseases or tube feeding or dysphagia i.e. pneumonia
people with insulin injection or use GLP-1 analogues drugs or DPP-4 inhibitors drugs
people with history of bariatric surgery, gastroparesis, malabsorption
people with history of diseases that affect blood glucose/lipid control i.e. hyperthyroidism, endocrinology and kidney disorders
use long-term immunosuppressants
cancer patient
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