Dietary Nitrate and Erectile Dysfunction

  • End date
    Aug 1, 2021
  • participants needed
  • sponsor
    University Hospital, Essen
Updated on 3 February 2021


An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion injury and hypertension. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet. Nitrate improves vascular functions in old adults and improves ischemia reperfusion injury in experimental models.

Whether dietary nitrate improves erectile dysfunction is not known and will be investigated in the present study.

Condition Impotence, Erectile Dysfunction
Treatment Control, Dietary Nitrate
Clinical Study IdentifierNCT04116060
SponsorUniversity Hospital, Essen
Last Modified on3 February 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 40 yrs and 75 yrs?
Are you male?
Do you have any of these conditions: Erectile Dysfunction or Impotence?
Is your age between 30 yrs and 80 yrs?
Do you have any of these conditions: Impotence or Erectile Dysfunction?
Patients with erectile Dysfunction (IIEF5: 8-21) PDE-5 Inhibitors Responder
Aged 30-80 years

Exclusion Criteria

Spinal cord disease
Insulin dependent Diabetes mellitus
Prostate cancer after operation, radiotherapy and hormone therapy
Treatment with NO-Donators or sGC-Activators
Chronic kidney disease (Stage IV-V)
Advanced liver dysfunction
Clear my responses

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