Multimodal Ophthalmic Imaging

  • End date
    Jun 30, 2023
  • participants needed
  • sponsor
    Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Updated on 23 January 2021


Knowledge of the pathogenesis of ocular conditions, a leading cause of blindness, has benefited greatly from recent advances in ophthalmic imaging. However, current clinical imaging systems are limited in resolution, speed, or access to certain structures of the eye.

The use of a high-resolution imaging system improves the resolution of ophthalmoscopes by several orders of magnitude, allowing the visualization of many microstructures of the eye: photoreceptors, vessels, nerve bundles in the retina, cells and nerves in the cornea.

The use of a high-speed acquisition imaging system makes it possible to detect functional measurements such as the speed of blood flow. The combination of data from multiple imaging systems to obtain multimodal information is of great importance for improving the understanding of structural changes in the eye during a disease.

The purpose of this project is to observe structures that are not detectable with routinely used systems.


The goal of the project is the capture and analysis of images with the IMA-MODE systems, in order to evaluate the performance of these systems compared to the existing clinical imaging devices used at the National Hospital of Ophthalmology.

This project should identify the best techniques to image the eye, and select the most promising techniques to evolve towards a possible development of a medical device.

Condition NIDDM, Diabetes Mellitus, Retinal Detachment, Retinal Degeneration, Macular corneal dystrophy, Dry eye syndrome, Trauma, Vascular Diseases, Hypertension, Cerebrovascular accident, Ocular Hypertension, Glaucoma, Macular Edema, age-related macular degeneration, Keratoconus, Wounds - qualifier, Retinitis Pigmentosa, Keratoconjunctivitis Sicca, Diabetes Mellitus, Type 2, Diabetes Prevention, Diabetes and Hypertension, Diabetes Mellitus Types I and II, High Blood Pressure (Hypertension), High Blood Pressure (Hypertension - Pediatric), Vascular Inflammation, Maculopathy, Diabetes (Pediatric), Elevated Blood Pressure, Dry Eyes, Cystoid Macular Edema, Macular Degeneration, Stroke, Wounds, Diabetes Mellitus Type 2, Diabetes, type 2 diabetes mellitus, traumatic injury, eye dryness, high blood pressure, arterial hypertension, traumatic disorder, corneal dystrophy, detached retina, diabetes mellitus (dm), type 2 diabetes, type ii diabetes, noninsulin-dependent diabetes mellitus, diabetes type 2, dry eye, cerebrovascular accidents, strokes, cerebral
Treatment High-resolution retinal imaging through adaptive optics, High-resolution retinal imaging through holographic systems
Clinical Study IdentifierNCT04129021
SponsorCentre Hospitalier National d'Ophtalmologie des Quinze-Vingts
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

People over 18
Patient with a pathology affecting the eye or healthy volunteer
Participant who signed the consent
Beneficiaries of the health insurance

Exclusion Criteria

Patients with a history of photosensitivity
Patients who have just received a photodynamic therapy treatment (
Patients taking drugs with photosensitivity as a side effect
Persons with pacemakers or other implanted electronic medical device
Patients with viral conjunctivitis or any other infectious disease
Patients with skin lesions on the neck or forehead
Patients at high risk of damage from optical radiation, such as aphakic patients, or patients with decreased sensitivity to light due to fundus disease
Pregnant or lactating women
Participant unable to be followed throughout the study
Vulnerable people
Subjects with predisposition to closure of the iridocorneal angle
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