Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms

  • STATUS
    Recruiting
  • End date
    Jul 7, 2025
  • participants needed
    380
  • sponsor
    Centre Hospitalier Universitaire de Nīmes
Updated on 10 October 2021
diagnostic procedure
dexamethasone
cushing's syndrome
free cortisol
urinary free cortisol

Summary

Automated immunodosage methods (Roche Elecsys cortisol and IDS cortisol dosing kits) offer a simple and inexpensive technology routinely used in a medical biology laboratory. They can be used to define robust diagnostic thresholds for salivary cortisol for the diagnosis of Cushing's syndrome and pseudo-Cushing combining the three tests performed as part of the patient's usual management. (ie two urinary free cortisol (UFC), the dexamethasone suppression test, and Diurnal variation of plasma cortisol).

Details
Condition Cushing's disease, Cushing's Disease
Treatment Blood test, 24-hour Urine test, Saliva swab, Dexamethasone test
Clinical Study IdentifierNCT03974789
SponsorCentre Hospitalier Universitaire de Nīmes
Last Modified on10 October 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

The patient is under consultation in the department of metabolic and endocrine disorders at the CHU Nimes for diagnosis or follow-up of hypercortisol assessment
The patient must be a member or beneficiary of a health insurance plan

Exclusion Criteria

The patient is pregnant, parturient or breastfeeding
The patient has a cardiovascular or metabolic state against the indication of dexamethasone
Patient with DFG < 30 ml/min/1.73 m2
The patient has suffered urinary incontinence rendering 24-hour urinary collection impossible or non-interpretable
The patient has a urinary catheter
The patient is taking corticoids (oral, inhaled, intra-venous or cutaneous)
Patient exposed to interfering treatments (Itraconazole, ritonavir, megestrol
acetate, medroxyprogesterone acetate, TSH, estrogen-progestogen pill, hormonal
coil)
The subject is in a period of exclusion determined by a previous study
The subject opposes their participation in the study
It is impossible to give the subject informed information
The patient is under safeguard of justice or state guardianship
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