Effect of Probiotics and Prebiotics in Renal Function in Septic Acute Kidney Injury Patients

  • End date
    Feb 4, 2023
  • participants needed
  • sponsor
    Hospital Civil de Guadalajara
Updated on 4 September 2021


Septic acute kidney injury is a condition associated with highly related to inflammatory molecules. Prebiotics and probiotics have shown to improve inflammatory cascade in animal model; In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.


Acute kidney injury is most commonly caused by sepsis, where endotoxemia and an expanding inflammatory reaction play a key role in its pathogenesis, when this condition is present it is highly related to poor clinical outcomes and higher mortality rates. There is no current specific treatment, and the therapeutic approach is more orientated to complication management. In this study, the investigators propose the use of probiotics to improve the clinical evolution of septic acute kidney injury patients.

Condition sepsis, systemic infections, sepsis syndrome, acute kidney injury, Kidney Failure, Renal Failure, acute kidney injuries, Septicemia, systemic infection, Kidney Failure (Pediatric), Sepsis and Septicemia, Probiotic, Acute renal failure
Treatment Placebo, probiotics
Clinical Study IdentifierNCT03877081
SponsorHospital Civil de Guadalajara
Last Modified on4 September 2021


Yes No Not Sure

Inclusion Criteria

Sepsis by SOFA
Acute kidney injury by KDIGO

Exclusion Criteria

No presence of sepsis
No presence of AKI
Age below 18 years
Inability or contraindication for oral capsules or probiotics by nasogastric tube
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