Determination of Factors Involved in the Regulation of Immune Responses After Allogeneic Hematopoietic Stem Cell Transplantation

  • End date
    Sep 30, 2026
  • participants needed
  • sponsor
    Central Hospital, Nancy, France
Updated on 23 January 2021


The study concerns donors and patients receiving allogeneic stem cell haematopoietic transplantation. The aim of the study is to analyse HSC graft content in immune effector T (naive, memory, activated, exhausted) and immunoregulatory cell subtypes (Tregs, iNKT, MDSC) and correlate the results with post-transplant immune reconstitution of those different cell subtypes and clinical events (graft-versus-host-disease, relapse, infections). An ancillary study will focus on the impact of microbiota dysbiosis on post-transplant immune response and regulatory cell subsets.

Condition Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation
Treatment Blood sample, bone marrow aspiration, Allogeneic hematopoietic stem cell sample
Clinical Study IdentifierNCT03357172
SponsorCentral Hospital, Nancy, France
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

patient of the Nancy CHRU, for whom a CSH allograft is planned. or
hematopoietic stem cell donors received at Nancy's CHRU for the duration of the research

Exclusion Criteria

Positive HIV
active hepatitis B or C infection
Clear my responses

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