Indoor Air Quality and Respiratory Morbidity in School-Aged Children With BPD

  • End date
    Jul 31, 2025
  • participants needed
  • sponsor
    Boston Children's Hospital
Updated on 23 January 2021


Investigators want to learn the role of indoor environmental exposures on respiratory symptoms, and, separately, on lung function deficits in school-aged children with bronchopulmonary dysplasia (BPD).


Bronchopulmonary dysplasia (BPD) is the most common respiratory disease affecting children born prematurely and leads to long-term respiratory symptoms and lung function impairment throughout childhood. This study will, evaluate the contribution of indoor sources of respiratory irritants to respiratory health impairment in school-aged children with BPD. State-of-the-art measures of indoor air quality constituents will assess the relationship of nitrogen dioxide (NO2), particulate matter (PM2.5), as well as, concentrations of allergens (mold, mouse, cockroach, pet), endotoxin, air temperature and humidity with concurrently measured respiratory symptoms and lung function in a well-characterized cohort of children with BPD. This research will identify specific harmful components of the indoor environment associated with respiratory morbidity and poor lung function in children with BPD.

Investigators will ask the participants to come in for a one time clinic visit for undergoing procedures as well as answering questions regarding health and home environment. During the 1 year of participation there will also be 2 home assessment visits where investigators will take a sample of the home environment as well record home characteristics.

Condition Environmental Exposure, Bronchopulmonary Dysplasia, bronchopulmonary dysplasia (bpd), environmental exposures, Chronic Lung Disease of Newborn
Clinical Study IdentifierNCT04107701
SponsorBoston Children's Hospital
Last Modified on23 January 2021


Yes No Not Sure

Inclusion Criteria

children 6-12 yrs old
born <32 wks gestational age
diagnosis of BPD or > 28 days of oxygen or respiratory support

Exclusion Criteria

major airway or chest surgery
physical or mental impairment that will prevent from doing spirometry
plans to move out of state within the next 9 months
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