Visual Study of Molecular Genotype in Glioma Evolution

  • STATUS
    Recruiting
  • End date
    Dec 31, 2022
  • participants needed
    1000
  • sponsor
    Tongji Hospital
Updated on 23 January 2021

Summary

The key molecular changes in the progression of glioma are closely related to tumor heterogeneity, pathological grade, precision treatment and prognosis of glioma. At present, a visually quantitative assessment criteria about the key molecular typing of glioma is still absent. Based on the previous research, this project intends to establish a multi-dimensional database of glioma from clinical, radiomics and microomics levels. The investigators aim to filter out the specific molecular markers in the progression of glioma and explore the intrinsic connection of radiomics features and microomics molecular markers by using bioinformatics integration analysis and artificial intelligence multiple kernel learning. Thus, the investigators could determine the specific molecular mechanism in the progression of glioma, and establish a visually quantitative assessment system of pre-operative precisive grading, molecular typing discrimination and prognosis prediction. The completion of this project is of great significance for improving molecular diagnostic level of glioma, guiding individualized diagnosis and treatment decisions, and improving the survival rate of patients.

Details
Condition Glioma of Brain, Intracranial Glioma
Clinical Study IdentifierNCT03750890
SponsorTongji Hospital
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Gender: Male or Female
Do you have any of these conditions: Glioma of Brain or Intracranial Glioma?
postoperative pathological and genetic test confirmed brain glioma
The preoperative Clear and complete multimodal imaging data were collected within 10 days

Exclusion Criteria

patients who underwent surgery more than 4 weeks after MRI
patients with motion artifacts
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