Sleep-dependent Learning in Aging

  • STATUS
    Recruiting
  • End date
    Jul 15, 2024
  • participants needed
    584
  • sponsor
    University of Massachusetts, Amherst
Updated on 23 January 2021

Summary

The specific objective of this proposed research is to understand whether deficits in sleep-dependent memory changes reflect age-related changes in sleep, memory, or both. The central hypothesis is that changes in both memory and sleep contribute to age-related changes in sleep-dependent memory processing. To this end, the investigators will investigate changes in learning following intervals of sleep (overnight and nap) and wake in young and older adults.

Description

Exp 1: Using neuroimaging, the investigators will consider whether differences in brain areas engaged during memory encoding contribute to age-related changes in sleep-dependent memory consolidation for a word-pair learning task.

Exp 2: The investigators will examine the rate of memory decay between encoding and sleep using two probes of declarative memory (word-pair learning and visuo-spatial learning).

Exp 3: The investigators will provide additional opportunity for encoding of the word-pair and visuo-spatial learning tasks.

Exp 4: Using neuroimaging, the investigators will examine neural engagement during encoding and performance following intervals of sleep and wake.

Exp 5: The investigators will examine the rate of decay of motor sequence learning.

Exp 6: The investigators will examine whether enhanced training ('overtraining') improves sleep-dependent memory consolidation for older adults.

Details
Condition Sleep
Treatment sleep
Clinical Study IdentifierNCT03840083
SponsorUniversity of Massachusetts, Amherst
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18-75 yrs
Healthy sleeper
No diagnosed sleep or neurodegenerative disorder

Exclusion Criteria

Past diagnosis of any sleep disorder or evidence of a sleep disorder as assessed by self-reported sleep quality assessments, a standardized diagnostic interview, and an acclimation night of polysomnography. Using acclimation-night polysomnography, participants will be excluded with an Apnea-Hypopnea Index >15; a Period-Limb Movement in Sleep index of >15/hr; sleep-onset latency > 45 min (indicative of insomnia); or sleep efficiency < 80% (see Edinger et al., Sleep, 2004). In cases in which questions arise regarding a participants' inclusion or sleep records, a practicing neurologist board-certified in sleep medicine will review the documentation
Past diagnosis neurological illness or head injury
Reported average sleep per night < 5 or > 9 hrs
Current employment involving shift work or an inability to keep a regular sleep schedule during the week prior to testing
Current use of psychotropic, recreational drugs, or sleep-altering medications (sleep medications, cold medicines within the past week, clonidine, sympathomimetic stimulants)
Daily caffeine intake of > 4 cups (coffee, tea, colas)
Weekly alcohol intake of > 10 cups
Pregnancy or < 12 months post-partum
History of bipolar disorder, mania, or current evidence of depression as measured by Beck Depression Inventory score > 25
Abnormal sleep (e.g., shift work, travel across >2 time zones within the past 3 months)
Diagnosis of any Axis I disorder, neurological illness or head injury (according to Demographic and Health History form)
Score indicative of cognitive dysfunction (subtest scores < 40)
Beck Depression Scale score indicative of depression (> 19)
Additionally, individuals will be excluded from magnetic resonance imaging
studies (Exps 1, 4) for
Left handed or ambidextrous
Claustrophobia
Presence of metal (thoroughly screened via questionnaire and metal detector)
Pregnancy
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