A Study of Anti-PD-1 AK105 in Patients With Metastatic Squamous Non-small Cell Lung Cancer

  • STATUS
    Recruiting
  • End date
    Dec 31, 2021
  • participants needed
    338
  • sponsor
    Akeso
Updated on 22 January 2021

Summary

This is a phase III, randomized, double-blinded, multicenter clinical study to evaluate the efficiency and safety of AK105 (Anti-PD1 antibody) plus paclitaxel and carboplatin vs placebo plus paclitaxel and carboplatin as First-line Therapy in patients with metastatic squamous non-small cell lung cancer.

Details
Condition Squamous Cell Lung Cancer, Squamous Cell Carcinoma of Lung, Lung Cancer Non-small Cell Stage IV
Treatment carboplatin, Placebo, Paclitaxel, AK105
Clinical Study IdentifierNCT03866993
SponsorAkeso
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Signed written informed consent form voluntarily
Age over 18 years old (inclusive) and not more than 75 years old (inclusive), when signing the ICF
Eastern Cooperative Oncology Group (ECOG) performance score 0 or 1
Expected life expectance 3 months
Histologically or cytologically confirmed diagnosis of stage IV squamous NSCLC
No prior systemic chemotherapy for advanced or metastatic NSCLC. Subjects who have received prior adjuvant chemotherapy or neoadjuvant chemotherapy with curative intent, or definitive chemoradiotherapy for advanced disease, will be eligible provided that progression has occurred >6 months from last treatment
At least one measurable tumor lesion per RECIST 1.1 criteria. A lesion previously irradiated will not be considered a target lesion
Subjects must provide an available tumor tissue sample taken < 6 months prior to first dose of study treatment
Adequate organ function
Females of childbearing potential who are sexually active with a nonsterilized male partner must use at least one highly effective method of contraception
Nonsterilized males who are sexually active with a female partner of childbearing potential must use highly effective method of contraception from Day 1 and for 120 days after the last dose of investigational product

Exclusion Criteria

Subjects who are diagnosed as NSCLC that harbors an EGFR-sensitizing mutation or ALK gene translocation
Subjects with other histological types of NSCLC, including mixed squamous cell carcinoma and adenocarcinoma, and mixed carcinoma containing small cell lung carcinoma or neuroendocrine carcinoma
Received prior treatment with EGFR inhibitors or ALK inhibitors
Receipt of last radiotherapy or any anti-tumor treatment [chemotherapy, targeted therapy, immunotherapy, Chinese patent drugs with antitumor indications, or immunomodulators or tumor embolization] within 3 weeks prior to the first dose of study treatment
Prior exposure to any anti-PD-1, anti-PD-L1, anti-CTLA-4 antibody, or any other antibody or drug therapy for T cell co-stimulatory or checkpoint pathways, such as ICOS or agonists (e.g. CD40, CD137, GITR and OX40 etc)
Other invasive malignancies within 5 years, except for locally treatable (manifested as cured) malignancies, such as basal or skin squamous cell carcinoma, superficial bladder cancer, cervical or breast carcinoma in situ
Subjects with active, known or suspected autoimmune disease, or a medical history of autoimmune disease, with the exceptions of the following: vitiligo, alopecia, Grave disease, psoriasis or eczema not requiring systemic treatment within the last 2 years, hypothyroidism (caused by autoimmune thyroiditis) only requiring steady doses of hormone replacement therapy and type I diabetes only requiring steady doses of insulin replacement therapy, or completely relieved childhood asthma that requires no intervention in adulthood, or primary diseases that will not relapse unless triggered by external factors
Active or previously documented inflammatory bowel disease (e.g. Crohn's disease, ulcerative colitis or chronic diarrhea)
Subjects who require systemic corticosteroids (a dose equivalent to >10 mg/day prednisone) or other immunosuppressive drugs within 14 days prior to the first dose of study drug
Major surgery (as defined by the investigator) within 28 days prior to the first dose of study drug
Subjects who received non-thoracic radiotherapy >30 Gy within 4 weeks prior to the first dose, or thoracic radiotherapy >30 Gy within 24 weeks prior to the first dose study drug
History of gastrointestinal perforation and/ or fistula within 6 months prior to the first dose of study drug
Known history of primary immunodeficiency virus infection
Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation
Known history of interstitial lung disease
Known history of active tuberculosis (TB)
Serious infections within 4 weeks prior to the first dose of study drug, including but not limited to complications requiring hospitalization, sepsis or severe pneumonia
An active infection requiring systemic therapy
Subjects with untreated chronic hepatitis B or chronic hepatitis B virus (HBV) DNA exceeding 500 IU/ mL or active hepatitis C virus (HCV) should be excluded. Subjects with non-active HBsAg carriers, treated and stable hepatitis B (HBV DNA <500 IU/ mL) , and cured hepatitis C can be enrolled. Subjects with positive HCV antibodies are eligible only if the HCV RNA test results are negative
Known history of testing positive for human immunodeficiency virus (HIV)
Presence of central nervous system (CNS) metastasis, meningeal metastasis, spinal cord compression, or leptomeningeal disease
Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage
Clinically active hemoptysis, active diverticulitis, peritoneal abscess, or gastrointestinal obstruction
Clinically significant bleeding symptoms or significant bleeding tendency such as gastrointestinal bleeding, hemorrhagic gastric ulcer or vasculitis within 1 month prior to the first dose of study treatment
Unresolved toxicities from prior anticancer therapy, defined as having not resolved to NCI CTCAE v4.03 Grade 0 or 1, or to levels dictated in the inclusion/exclusion criteria, with the exception of alopecia
Receipt of live or attenuated vaccination within 30 days prior to the first dose of study treatment, or plan to receive live or attenuated vaccine during the study
Known history of server hypersensitivity to other monoclonal antibodies
Known severe allergic reactions to paclitaxel, carboplatin, or their preventive medications
Grade 2 or greater peripheral neuropathy (based on NCI CTCAE v4.03 criteria)
Known allergic reactions to any ingredients of AK105
Pregnant or lactating women
Any conditions that, in the investigator's opinion, may put subjects treated with the study drug at risks, or interfere with the evaluation of study drug or subject safety, or the interpretation of study results
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