Idiopathic Scoliosis Progression and Sleep-disordered Breathing in Children
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- STATUS
- Recruiting
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- End date
- Feb 18, 2023
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- participants needed
- 300
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- sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Summary
This study aimed to investigate the prevalence and clinical significance of sleep-disordered breathing (SDB) in children with mild-moderate idiopathic scoliosis (IS).
Description
Idiopathic scoliosis (IS) is the most common pediatric musculoskeletal disorder that causes a three-dimensional spinal deformity affecting 2 to 4% of adolescent subjects. It can be progressive (in 3 out of 10 cases) and severe involving serious effects (spine pain, cardiopulmonary compromise, deformed torso, psychosocial issues) and heavy treatments (corset, surgery). However, there is still no reliable criteria to predict the occurrence and progression of IS, while the etiology of IS remains unclear.
Sleep-disordered breathing (SDB) in children is a common condition characterized by recurrent events of upper airway obstruction during sleep. The major symptom is snoring or noisy breathing. Preliminary evidence suggests that SDB in children is associated with low bone mass and postural stability, which might be mechanisms in the development of scoliosis. However, the influence of SDB on the progression of IS remains unknown.
To fill those gaps, investigators will perform a prospective, unrandomized, observational cohort study to determine the prevalence and significance of SDB in children with mild-moderate IS. All subjects will be screened with a designated sleep questionnaire (PSQ), and children with either severe daytime sleepiness or frequent snoring or any degree of sleep pause will be requested to undergo further evaluation and an overnight polysomnography (PSG). Routine follow-up visits will be scheduled 6 months apart up to 24 months to assess the curve progression of scoliosis.
Details
| Condition | Sleep apnea, Sleep Apnea Syndromes, Obstructive sleep apnea, Scoliosis Idiopathic, Sleep Apnea Syndromes, sleep-disordered breathing, obstructive sleep apnoea, obstructive sleep apnea syndrome, sleep disordered breathing |
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| Clinical Study Identifier | NCT03858244 |
| Sponsor | Second Affiliated Hospital of Wenzhou Medical University |
| Last Modified on | 22 January 2021 |
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