The Safety and Efficacy of Deferoxamine for Treating Unresectable Hepatocellular Carcinoma
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- STATUS
- Recruiting
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- End date
- Dec 31, 2023
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- participants needed
- 100
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- sponsor
- Jinan Military General Hospital
Summary
To investigate the safety and efficacy of deferoxamine (DFO) combined with conventional transarterial chemoembolization (TACE) in patients with unresectable hepatocellular carcinoma (HCC).
Description
DFO, an iron chelator, is considered as a potential drug to the treatment of HCC. Ferrum is an important transition metal for organisms and the liver plays a major role in its storage. However, in pathologic conditions, it will lead to hepatocyte injury through the free radicals generated by excess iron. In addition, excess iron accumulation in the liver increases toxic free iron, which is closely associated with hepatic inflammation, as well as the development and progression of HCC. Reduction of iron is likely an important therapeutic targets for treating HCC. Iron reduction therapy has been efficacious in both in animal HCC models and results of clinical studies also suggest potential efficacy for HCC. DFO chelates iron by forming a stable complex that prevents the iron from entering into further chemical reactions. The investigators assume that DFO, combined with TACE, may provide additional efficacy in patients with unresectable HCC.
Details
| Condition | Hepatocellular Carcinoma Non-resectable |
|---|---|
| Treatment | Conventional TACE, Deferoxamine and conventional TACE |
| Clinical Study Identifier | NCT03652467 |
| Sponsor | Jinan Military General Hospital |
| Last Modified on | 22 January 2021 |
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