Ruxolitinib Combined With Dexamethasone for HLH

  • STATUS
    Recruiting
  • End date
    Mar 1, 2022
  • participants needed
    50
  • sponsor
    Capital Research Institute of Pediatrics
Updated on 22 January 2021

Summary

A protocol named as "HLH-DR" for patients with refractory and secondary hemophagocytic lymphohistiocytosismay.

Description

A modified protocol about ruxolitinib combined with dexamethasone which includes oral ruxolitinib (2.5 mg twice daily for patients if the age<14 years and the weight <25kg5 mg twice daily for patients if the age<14 years and the weight25kg, 10mg twice daily for patients if the age 14 years and<18 years. Dexamethasone (10mg/m2.d) delayes for the first 2 weeks form week 1 to 2(5mg/m2.d) from week 3 to 4(2.5mg/m2.d) from week 5 to 61.25mg/m2.d for week 7and dropped off on week 8. Every 2 weeks, patients can be evaluated based the diagnosed index

Details
Condition Hemophagocytic lymphohistiocytosis
Treatment Ruxolitinib, Dexamethasone
Clinical Study IdentifierNCT03795909
SponsorCapital Research Institute of Pediatrics
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Secondary and refractory HLH

Exclusion Criteria

Family HLH
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