Ruxolitinib Combined With Dexamethasone for HLH

  • End date
    Mar 1, 2022
  • participants needed
  • sponsor
    Capital Research Institute of Pediatrics
Updated on 22 January 2021


A protocol named as "HLH-DR" for patients with refractory and secondary hemophagocytic lymphohistiocytosismay.


A modified protocol about ruxolitinib combined with dexamethasone which includes oral ruxolitinib (2.5 mg twice daily for patients if the age<14 years and the weight <25kg5 mg twice daily for patients if the age<14 years and the weight25kg, 10mg twice daily for patients if the age 14 years and<18 years. Dexamethasone (10mg/m2.d) delayes for the first 2 weeks form week 1 to 2(5mg/m2.d) from week 3 to 4(2.5mg/m2.d) from week 5 to 61.25mg/m2.d for week 7and dropped off on week 8. Every 2 weeks, patients can be evaluated based the diagnosed index

Condition Hemophagocytic lymphohistiocytosis
Treatment Ruxolitinib, Dexamethasone
Clinical Study IdentifierNCT03795909
SponsorCapital Research Institute of Pediatrics
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Secondary and refractory HLH

Exclusion Criteria

Family HLH
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note