PET-FDG in Myocarditis

  • STATUS
    Recruiting
  • days left to enroll
    85
  • participants needed
    50
  • sponsor
    Montreal Heart Institute
Updated on 21 March 2021

Summary

This study evaluates the diagnostic performance of 18F-2-fluoro-2-deoxy-D-glucose fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) with rest perfusion imaging for the diagnosis of myocarditis. Patients with clinical suspicion of myocarditis will be recruited and undergo a rest myocardial perfusion scan and a FDG PET/CT scan following a myocardial suppression protocol.

Description

Myocarditis is characterized by myocardial inflammation, which can lead to fibrosis and heart failure.

FDG PET/CT, with appropriate suppression protocol including high-fat-low-carbohydrate diet, fasting, and IV heparin, can be use to detect myocardial inflammation. It is frequently used for the diagnosis of inflammation in cardiac sarcoidosis. After the initial inflammatory phase, inflammation resolves and fibrosis can seen. Resting perfusion imaging will allow identification of fibrosis. The combination of FDG PET/CT and rest perfusion imaging could allow detection of the various phases of myocarditis; inflammation and fibrosis.

Details
Condition Cardiomyopathy, Cardiomyopathy, Myocarditis, Viral Myocarditis
Treatment FDG PET/CT
Clinical Study IdentifierNCT03777839
SponsorMontreal Heart Institute
Last Modified on21 March 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

18 years of age or older
Clinical suspicion of myocarditis due to findings such as
Symptoms and signs of myocarditis such as dyspnea, orthopnea, palpitation, and chest pain, without other identifiable cause
New onset of cardiovascular symptoms with recent history of viral disease or previous myocarditis
Unexplained new onset of left ventricular dysfunction
Unexplained elevated troponin
Magnetic resonance imaging findings suggestive of myocarditis, such as late gadolinium enhancement and edema
Biopsy findings compatible with myocarditis
Women of childbearing potential must have a negative urine or blood pregnancy test
Capable of giving informed consent and the consent must be obtained prior to any study related procedures
Subject's with body mass index inferior or equal to 45 kg/m2

Exclusion Criteria

Female subject who is pregnant or breastfeeding and unwilling to stop for 24h
Claustrophobia or inability to lie still in a supine position for imaging purposes
Unwillingness or inability to provide informed consent
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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