Cost-effectiveness of Adalimumab and Surgery vs Adalimumab in HS

  • STATUS
    Recruiting
  • participants needed
    128
  • sponsor
    Erasmus Medical Center
Updated on 10 August 2022

Summary

The primary objective of this randomized controlled clinical trial in a real life setting is to evaluate the cost-utility of limumab monotherapy compared with the combination of adalimumab and a maximum of three surgeries after two years of treatment in adult patients with moderate to severe HS.

Description

The primary objective of this randomized controlled clinical trial in a real life setting is to evaluate the cost-utility of limumab monotherapy (Group A) with the combination of adalimumab and a maximum of three surgeries (Group B) years of treatment in adult patients with moderate to severe HS.

Patients in group A will be treated with adalimumab monotherapy according to normal clinical practice and will be given the possibility to crossover into Group B when they do not achieve the HiSCR after 6 months of treatment. Additionally patients will be offered treatment with infliximab, according to clinical practice, until the last surgery. Patients in group B will receive adalimumab combined with a maximum of three adjuvant excisions of active lesions, both according to routine clinical practice.

Details
Condition Hidradenitis Suppurativa, Acne Inversa, Acne Inversa
Treatment Adalimumab Injection, Wide Excision
Clinical Study IdentifierNCT03221621
SponsorErasmus Medical Center
Last Modified on10 August 2022

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