Comparison of Cilostazol-based Triple Antiplatelet Therapy Versus Dual Antiplatelet Therapy for Outcomes of below-the Knee Endovascular Intervention in Patients With Critical Limb Ischemia (TAP CLI Study)

  • End date
    Oct 22, 2021
  • participants needed
  • sponsor
    Yonsei University
Updated on 22 January 2021


  • Prospective, randomized, controlled, multi-center study
    • A total of 390 subjects with critical limb ischemia will be included according to inclusion and exclusion criteria.
    • Patients will be randomized in a 1:1:1 manner into triple antiplatelet therapy (TAP: aspirin, clopidogrel, cilostazol) group, dual antiplatelet therapy (DAP: aspirin, clopidogrel) A group, or DAP (aspirin, cilostazol) B group.
    • All patients will be treated with angioplasty for critical limb ischemia.
    • Patients will be followed clinically for 1 year after the procedure.
    • Ankle-brachial index and Image study follow-up (Duplex US or CT angiography) will be performed at 1 year.

Condition Critical Limb Ischemia, Critical Limb Ischaemia
Treatment Triple antiplatelet therapy (aspirin (100 mg), clopidogrel (75 mg), and cilostazol (200 mg) ), Dual antiplatelet therapy (aspirin (100 mg) and clopidogrel (75 mg)) using aspirin and clopidogrel, Dual antiplatelet therapy (aspirin (100 mg) and cilostazol (200 mg)) using aspirin and cilostazol
Clinical Study IdentifierNCT02829151
SponsorYonsei University
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Is your age between 19 yrs and 85 yrs?
Gender: Male or Female
Do you have any of these conditions: Critical Limb Ischaemia or Critical Limb Ischemia?
Patients 19 years old
Patients with critical limb ischemia (Rutherford 4 & 5)
Successful below-the knee endovascular intervention

Exclusion Criteria

Major bleeding event within recent 3 months or high risk of major bleeding
Patients requiring anticoagulation
Allergic reactions to antiplatelet drugs
Acute limb ischemia
Severe hepatic dysfunction (3 times normal reference values)
Pregnant women or women with potential childbearing
Life expectancy < 1 year due to comorbidity
Previous amputations in the target limb
Clear my responses

How to participate?

Step 1 Connect with a site
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact


Phone Email

Please verify that you are not a bot.

Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note