Cryotherapy Versus Radiofrequency Catheter Ablation Research Program

  • End date
    Jun 22, 2023
  • participants needed
  • sponsor
    St. George's Hospital, London
Updated on 22 January 2021


A program of research has been set up at St. George's Hospital, London studyng the practicalities of catheter ablation. The current practice of catheter ablation is being studied for a range of arrhythmias including PAF, persistent AF, advanced persistent AF and resistant WPW.


The study design will be a separate randomised clinical trial for each of the arrhythmias studied. There will be 1:1 randomisation to either the cryotherapy protocol or RF protocol. Arrhythmia patients already under the care of this cardiac centre, who have already opted for catheter ablation treatment will be approached to ask if they will also be willing to participate in this longterm research program.

The protocols for each different arrhythmia are in line with current practice and knowledge and utilising current technology. In the program, the investigators have 1 or 2 protocols that mildly differ from conventional use but have already passed through initial experience with publication on this- this is the multi-catheter cryocatheter approach.

Acute procedural outcomes, short, medium and longterm success will be recorded for each patient, in addition to patient or participant experience and quality of life outcomes.

The catheter ablation research program has passed through ethical panel review in London and has the potential to become a multi-centre study.

Condition Wolff-Parkinson-White Syndrome, Arrhythmia, Dysrhythmia, Arrhythmia, Atrial Fibrillation, Atrial Fibrillation, Atrial Fibrillation (Pediatric), Tachycardia, Fast Heart Rate (Tachycardia), Ventricular tachycardia, Fast Heart Rate (Tachycardia), Atrial Tachycardia, Atrial Fibrillation (Pediatric), Dysrhythmia
Treatment Cryotherapy, radiofrequency catheter ablation
Clinical Study IdentifierNCT03816033
SponsorSt. George's Hospital, London
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Adult patients under the care of the Arrhythmia Service at St. George's Hospital with one of the studied arrhythmia (PAF, persistent AF etc), awaiting catheter ablation treatment will be eligible for inclusion to the program of research

Exclusion Criteria

Vulnerable patients will be excluded- e.g. active cancer, inability to consent
Paediatric patients will not be studied
Patients awaiting standard SVT catheter ablation treatment
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