Post Transplant Cyclophosphamide in Matched Unrelated Donor Stem Cell Transplantation for Hematological Malignancies

  • STATUS
    Recruiting
  • End date
    Nov 1, 2026
  • participants needed
    50
  • sponsor
    Hospital Israelita Albert Einstein
Updated on 22 January 2021

Summary

This study aims to evaluate the clinical efficacy of cyclophosphamide in patients receiving a bone marrow graft from a matched unrelated donor in overall survival, progression free survival and cumulative incidence of acute and chronic GvHD. Thirty patients will receive cyclophosphamide while twenty patients will receive antihuman T-lymphocyte immune globulin (ATG).

Details
Condition Graft-Versus-Host Disease, Graft-Versus-Host Disease (GVHD), Viral infection, Viral Infections, Graft-Versus-Host Disease (GVHD), Viral Infections, Bone Marrow Transplant Complications, Engraft Failure, graft versus host disease, graft-versus-host-disease, Immunologic Suppression
Treatment cyclophosphamide, ATG
Clinical Study IdentifierNCT03818334
SponsorHospital Israelita Albert Einstein
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Men and Women of Any Age
Indication for an HSCT without matched sibling donor
Have a matched unrelated donor (HLA 10 x 10 or 9 x 10)
Hematological malignancy

Exclusion Criteria

Acute leukemias not in complete response (that is > 5% blast in the bone marrow)
Chemorefractory lymphoproliferative disease
Active uncontrolled infection
HCT-CI > 3
Severe organic disfunction (heart ejection fraction < 45%, glomerular filtration rate < 50 mL.hour, pulmonary DLCO < 50%)
Previous allogeneic bone marrow transplantation
Contraindication to cyclophosphamide or ATG
Clear my responses

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