Randall's Plaque Study: Pathogenesis and Relationship to Nephrolithiasis

  • STATUS
    Recruiting
  • End date
    Dec 25, 2025
  • participants needed
    600
  • sponsor
    Indiana Kidney Stone Institute
Updated on 25 January 2021
calcium
nephrolithiasis
uropathy

Summary

Kidney stones are very common. They affect 3-5% of the population in the United States. Many people are hospitalized for the treatment of kidney stones and some may die. Better understanding of what causes kidney stones is useful in both the treatment and prevention of kidney stones. However, exactly what causes kidney stones is unknown.

The most common type of kidney stones contains calcium, which sometimes is attached to a part of the kidney important in producing the final urine, called the papilla. The investigators have noticed that persons who form kidney stones seem to have more papilla with stones attached. They propose to study these areas of the papilla, called Randall's plaques (named after their discoverer), in patients undergoing surgery for kidney stones.

Description

In order to attempt to explain the pathogenesis of renal calculi, the investigators videotape and document the location and characteristics of each stone, papillae and calyces. One or more small papillary biopsies are taken for analysis to help determine the point of origin of the kidney stone and histological studies are undertaken to determine tissue differences amongst different types of stone formers. Approximately one month after surgery, metabolic studies are undertaken to further review potential causes of stone formation.

Details
Condition Cystinuria, Hypercalciuria, Hyperparathyroidism, Nephrocalcinosis, Nephropathy, PARATHYROID DISORDER, Nephrolithiasis, KIDNEY STONE, Kidney Disease (Pediatric), Hyperparathyroidism (Pediatric), Parathyroid Disorders, Kidney Stones, Kidney Disease, Parathyroid Disease, renal stones, renal lithiasis
Treatment videotape for mapping of renal anatomy and papillary biopsy
Clinical Study IdentifierNCT00169806
SponsorIndiana Kidney Stone Institute
Last Modified on25 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Patients of Methodist Urology in Indianapolis, IN who are undergoing endoscopic procedures for nephrolithiasis or other urologic disease
Upper urinary tract endoscopic or PERC procedure for kidney stones removal
General medical health allowing surgical procedure
Ability to complete all the necessary components of the study
Able to sign an informed consent

Exclusion Criteria

Poor general medical health
Bleeding diathesis
Inability or unwillingness to comply with post-surgical follow-up
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