Comparison of Water Sorption Capacity and the Composition of Bronchial Fluids of Healthy Persons and Patients With Chronic Obstructive Bronchitis (COPD)

  • End date
    Oct 3, 2021
  • participants needed
  • sponsor
    Georg Nilius, PD DR med
Updated on 3 February 2021


Pilot basic research study on the properties of bronchial mucus. Examination of the sorption and desorption properties, mucin concentration, and structure of the mucus from healthy airways compared to patients with Chronic Obstructive Pulmonary Disease (COPD).


Mucus, of the correct composition, maintains airway hydration and protects the airway from inhaled particles through mucociliary transport. In chronic inflammatory airway diseases such as COPD or cystic fibrosis, infectious agents, inflammatory cells and products of inflammation such as DNA, increase mucus viscosity which results in decreased mucociliary clearance of inhaled particles, increasing the likelihood of respiratory infections. This pilot study is planned as basic research on the properties of bronchial mucus.

Water isotherms and efficient water activity (sorption and desorption) of the collected samples are examined in defined temperature and humidity settings using DVS Intrinsic (Dynamic Vapour Sorption System, Surface Measurement Systems, London, UK). Findings will provide insights into possible treatment programs targeted at altering specific mucus components.

Condition Chronic Obstructive Lung Disease, healthy, COPD (Chronic Obstructive Pulmonary Disease), Reactive Airway Disease, chronic obstructive pulmonary disease, COPD, chronic obstructive pulmonary disease (copd)
Clinical Study IdentifierNCT04703023
SponsorGeorg Nilius, PD DR med
Last Modified on3 February 2021


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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Chronic Obstructive Lung Disease or Reactive Airway Disease or chronic obstructive pulmonary disease (copd) or chronic obstructive pulmonary disease o...?
Do you have any of these conditions: chronic obstructive pulmonary disease (copd) or chronic obstructive pulmonary disease or healthy or Reactive Airway Disease or Chronic Obstructive Lun...?
COPD or other disease requiring bronchoscopy or elective surgery
Signed informed consent form

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Not able to consent
Linguistic, cognitive, or other obstacles
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