The Obese Taste Bud Study

  • End date
    Jul 30, 2022
  • participants needed
  • sponsor
    University of Leipzig
Updated on 30 January 2021


The sense of taste is essential for priming food preferences and is therefore important for caloric uptake and body weight regulation. Recent studies show that obesity is linked to changes in taste sensation but also to a loss of taste buds on the tongue. This study aims to evaluate underlying mechanisms within the taste buds to potentially influence the sense of taste on the level of these sensory cells and in order to develop new treatment strategies to fight obesity.

Condition adiposity, Obesity
Treatment Questionnaires, Oral glucose tolerance test, biospecimen collection, taste bud biopsy, Taste sensitivity, Taste sensitivity, olfactory function, taste bud density, anthropometry, anthropometry
Clinical Study IdentifierNCT04633109
SponsorUniversity of Leipzig
Last Modified on30 January 2021


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Inclusion Criteria

Is your age between 18 yrs and 69 yrs?
Gender: Male or Female
Do you have any of these conditions: adiposity or Obesity?
normal weight (BMI 18.5-24.9)
obesity (BMI >=30)
overall healthy (no severe sickness, no cancer)
written informed consent

Exclusion Criteria

current pregnancy or currently breastfeeding
cancer or tumors
state after radiotherapy at head-neck area
state after or current chemotherapy
severe psychiatric-, cardiac-, kidney- or neurological illness
diagnosed diabetes mellitus
known dysfunction of smelling or tasting
drug or alcohol abuse
permanent medication with antidepressants, anticonvulsants, steroids and/or immunosuppressants
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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