Additive Anti-inflammatory Action for Aortopathy & Arteriopathy (Rosuvastatin) I

  • STATUS
    Recruiting
  • End date
    Dec 31, 2023
  • participants needed
    300
  • sponsor
    Nanjing Medical University
Updated on 5 August 2021

Summary

Acute Aortic Syndrome (AAS)/Aortic Aneurysm is a common feature of aortic wall events, including aortic dissection, intramural hematoma, aortic ulceration and aortic trauma, and occurs in up to 35 cases per 100,000 cases per year between the ages of 65 and 75 years. Increased levels of the inflammatory biomarker high-sensitivity C-reactive protein predict cardiovascular events. Since statins lower levels of high-sensitivity C-reactive protein as well as cholesterol, the authors hypothesized that people with acute aortic syndrome but without hyperlipidemia might benefit from statin treatment.

Details
Condition Acute Aortic Syndrome, Aortopathy
Treatment Rosuvastatin 10mg
Clinical Study IdentifierNCT04699279
SponsorNanjing Medical University
Last Modified on5 August 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

(1) Patients with aortic dissection/ulceration/intermural hematoma/aortic aneurysm who underwent aortic arch replacement or endoluminal isolation or hybrid therapy
(2) Paitents without clinically significant hyperlipidemia but with cardiovascular disease risk factors (such as male 45 years old, female 55 years old, hypertension, diabetes, chronic kidney disease, obesity, low HDL cholesterol, smoking, alcohol consumption, family history of early onset ischemic cardiovascular disease) and no previous use of statins
(3) Patients are between 18 and 85 years old, male or female
(4) Agree to participate in the study and sign the informed consent

Exclusion Criteria

(1) Patients with allergy to statins
(2) patients with active liver disease
(3) patients with myopathy
(4) Lactating women and pregnant women
(5) Patients with mental diseases, drug and alcohol dependence
(6) Refuse to participate in the study or sign the informed consent
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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