Molecular Imaging Probes to Inform Heterogeneity in Idiopathic Pulmonary Fibrosis

  • STATUS
    Recruiting
  • End date
    Jun 1, 2023
  • participants needed
    10
  • sponsor
    University of Alabama at Birmingham
Updated on 20 June 2022
positron emission tomography
idiopathic pulmonary fibrosis
forced vital capacity

Summary

The purpose of the study is to see if imaging with fluorine-18 Fluorodeoxyglucose ([18F] FDG) and fluorine-18 Displacement Per Atom ([18F]DPA-714) using positron emission tomography and computed tomography (PET/CT) will show lung inflammation and fibrosis in patients diagnosed with idiopathic pulmonary fibrosis (IPF). This study may help physicians and researchers better understand how best to treat patients with IPF in the future.

Details
Condition Idiopathic Pulmonary Fibrosis
Treatment PET/CT using PET ligands [F-18]FDG and [F-18]DPA-714
Clinical Study IdentifierNCT04362644
SponsorUniversity of Alabama at Birmingham
Last Modified on20 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age between 40-85 years old
A diagnosis of IPF that fulfills American Thoracic Society (ATS) / European Respiratory Society (ERS) 2018 consensus criteria within 5 years
Ability and willingness to give informed consent and adhere to study requirements
Ratio of forced expiratory volume in 1 second to forced vital capacity (FEV1/FVC) >0.70
High or mixed affinity binder for TSPO ligands based on genotyping for single-nucleotide polymorphism (SNP)rs6971

Exclusion Criteria

Acute exacerbation of IPF within <30 days
Diagnosis of Diabetes Mellitus (Type 1 or Type 2)
Diagnoses of current infection by clinical or microbial assessments
Treatment for >14 days within the preceding month with >20 mg. prednisone (or equivalent) or any treatment during the last month with a cellular immunosuppressant
Subjects with prior radiation therapy to the thorax
Women who are pregnant, or who are breastfeeding. IPF is a disease of older adults, and male predominant, so this will not be a frequent consideration
Severe cardiovascular disease, defined as any of the following within the preceding 12 weeks: acute myocardial infarction or unstable angina, a coronary revascularization procedure, or stroke
Subjects with known liver disease
Diagnosis of any active cancer with the exception of basal cell carcinoma of skin
Low affinity binder for TSPO ligands based on genotyping for SNP rs6971
Active cigarette smoking or vaping
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