Diffusion-weighted MRI to Predict Treatment Response in Stereotactic Radiotherapy of Central Nervous System (CNS) Metastases

  • End date
    Dec 31, 2023
  • participants needed
  • sponsor
    Lund University Hospital
Updated on 27 January 2021


Stereotactic radiation therapy is an important and common method of treating brain metastases in patients with malignant disease. Today, however, there are no methods available to determine the metastasis' radiation sensitivity in advance and treatment responses can only be seen by changing of the size of the metastasis on conventional X-ray examinations, computed tomography (CT) and magnetic resonance imaging (MRI). Changes in the size of the metastases is something that is often seen weeks / months after treatment is completed. At Lund University Hospital, a new imaging technique, diffusional variance decomposition (DIVIDE), has now been developed. With this technique, the scatter in isotropic and anisotropic diffusion can be measured for each measuring point, which provides significantly more information about the properties of the tissue compared to current methods.

Condition Radiation Oncology, Radiotherapy, Sensitivity, radiotherapeutic, Brain Metastasis, Brain Metastases, Radionecrosis
Treatment Brain metastases radiation
Clinical Study IdentifierNCT04700748
SponsorLund University Hospital
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

Patients prescribed stereotactic radiation therapy to the brain, where MRI imaging is included in the treatment preparations
Cohesive remaining solid tumor component of 10mm
Age 18 years
World Health Organisation (WHO) performance status 0-1

Exclusion Criteria

Inability to decide for oneself on participation in the study
Inability to understand the Swedish language
Metastases close to the base of the skull
Contraindications to conducting an MRI examination
Contraindications to obtaining contrast media during MRI examination
Expected survival less than 6 months
Previous radiation treatment to the same site in the brain, i.e. current treatment is a rope radiation
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