Metabolic Effects of Exogenous 3-hydroxybutyrate in Patients With Type 1 Diabetes and Healthy Controls

  • STATUS
    Recruiting
  • End date
    Dec 19, 2022
  • participants needed
    20
  • sponsor
    University of Aarhus
Updated on 19 December 2021
diabetes
diabetic ketoacidosis
Accepts healthy volunteers

Summary

The main objective of this clinical trial is to study the metabolic effects of intravenous infusion of the ketone body, 3-hydroxybutyrate (3-OHB), in patients with type 1 diabetes and healthy control subjects. Moreover, the investigators plan to examine regulatory mechanisms of 3-OHB that may be related to diabetic ketoacidosis.

The hypotheses are:

  1. 3-OHB related inhibition of lipolysis is impaired in patients with type 1 diabetes.
  2. Intravenous infusion of 3-OHB affects signaling pathways involved in the metabolic regulation in patients with type 1 diabetes and healthy controls.
  3. 3-OHB infusion improves cardiac function in patients with type 1 diabetes and healthy controls.

The effects of 3-OHB will be investigated by isotopic tracers examinations, fat and muscle biopsies and blood samples. To evaluate effects on cardiac function echocardiography will be performed.

Details
Condition Type 1 Diabetes Mellitus, Diabetic Ketoacidosis
Treatment 3-hydroxybutyrate, 3-hydroxybutyrate
Clinical Study IdentifierNCT04656236
SponsorUniversity of Aarhus
Last Modified on19 December 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

< BMI < 26
written consent

Exclusion Criteria

Chronic disease
Regular medication (except over-the-counter medicines)
PI finds the patient not fit (e.g. mental illness, too nervous, unacceptable screening blood tests or other)
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