Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKD

  • days left to enroll
  • participants needed
  • sponsor
    University of Colorado, Denver
Updated on 19 December 2021


This is a pilot, randomized, double-blinded, placebo-controlled, 12-month trial of 50 patients with CKD stage 3b-4 with metabolic acidosis to examine the effect of sodium bicarbonate therapy on cognitive and cerebrovascular function.

Condition Metabolic Acidosis, Chronic Kidney Disease, Cognitive Dysfunction
Treatment Placebo, Sodium Bicarbonate Tablets
Clinical Study IdentifierNCT04600323
SponsorUniversity of Colorado, Denver
Last Modified on19 December 2021


Yes No Not Sure

Inclusion Criteria

Age 50-75 years old
Serum bicarbonate 16-22 mEq/L on 2 separate measurements (at least 1 day apart)
CKD stage 3b or 4 at time of screening (eGFR 15-44 ml/min/1.73m2)
Blood pressure <130/80 mm Hg prior to randomization
Use of angiotensin converting enzyme inhibitor or angiotensin receptor blocker
Stable anti-hypertensive regimen for at least one month prior to randomization
Montreal Cognitive Assessment Score > 24
No history of stroke
No history of dementia
No history of neurologic disease
Able to provide consent

Exclusion Criteria

• Significant comorbid conditions that lead the investigator to conclude
that life expectancy is less than 1 year
Use of chronic daily oral alkali within the last 3 months (including sodium
bicarbonate, calcium carbonate or baking soda)
Uncontrolled hypertension
Serum potassium < 3.3 or ≥ 5.5 mEq/L at screening
Factors judged to limit adherence to interventions
New York Heart Association Class 3 or 4 heart failure symptoms, known EF ≤30%, or
Anticipated initiation of dialysis or kidney transplantation within 12 months
hospital admission for heart failure within the past 3 months
Current participation in another research study
Pregnancy or planning to become pregnant or currently breastfeeding
Chronic use of supplemental oxygen
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note