Social Cognition in Patients With Amyotrophic Lateral Sclerosis

  • End date
    Sep 27, 2023
  • participants needed
  • sponsor
    University Hospital, Angers
Updated on 27 January 2021


Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function. The clinical hallmark of Amyotrophic Lateral Sclerosis is the combination of upper and lower motor neuron signs and symptoms. The most recent studies suggest that up to 50% of Amyotrophic Lateral Sclerosis patients demonstrate mild to moderate cognitive disturbance. Impaired social cognition, including a deficit in the recognition of facial emotions and the identification of vocal prosody, is recognized as a part of the cognitive phenotype of Amyotrophic Lateral Sclerosis, with crucial implications for patients' and caregivers' training. However, studies remain scarce and the data acquired must be supported. The evolution of these manifestations during the disease is still poorly understood.

In this study the investigators aim to assess the social cognition capacities of patients with Amyotrophic Lateral Sclerosis compared to healthy matched control subjects.

Condition Social Cognition
Treatment neuropsychological test
Clinical Study IdentifierNCT04406675
SponsorUniversity Hospital, Angers
Last Modified on27 January 2021


Yes No Not Sure

Inclusion Criteria

Patient Amyotrophic Lateral Sclerosis
Education of at least 7 years
Native language: French
Patients Amyotrophic Lateral Sclerosis
Signature of informed consent to participate in the study
Accompanied patient
Control subject
People without any pathology
Education of at least 7 years
Native language: French
Signature of informed consent to participate in the study

Exclusion Criteria

Patient Amyotrophic Lateral Sclerosis and control subject
Simultaneous participation in another interventional protocol with experimental treatment
Inability to perform cognitive study tests
Pregnant, lactating or parturient women
Persons deprived of their liberty by administrative or judicial decision
Persons under psychiatric care under duress
Persons subject to legal protection measures
Persons out of state to express their consent
People not affiliated or not beneficiaries of a social security scheme
History likely to disturb cognition
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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