Niraparib + Dostarlimab In BRCA Mutated Breast Cancer

  • STATUS
    Recruiting
  • End date
    Jul 17, 2029
  • participants needed
    62
  • sponsor
    Dana-Farber Cancer Institute
Updated on 12 July 2022
estrogen
carcinoma
progesterone
HER2
progesterone receptor
erbb2
estrogen receptor
breast carcinoma
invasive breast cancer
BRCA1
BRCA2
lumpectomy
palb2
breast cancer staging
core needle biopsy

Summary

This research study involves pre-operative therapy that is specifically targeted for breast cancer in individuals with BRCA and PALB2 mutations.

The names of the study drugs involved in this study are:

  • Niraparib (Zejula)
  • Dostarlimab

Description

The research study procedures include screening for eligibility and study treatment including laboratory evaluations, two mandatory research biopsies, imaging assessments, and follow up visits.

Participants will receive treatment for 18 weeks. After 18 weeks, participants will be evaluated to determine if a candidate for surgery or if additional treatment outside of the study.

Participants with triple negative breast cancer will be randomized to one of two treatment arms.

  • Arm A: Niraparib with Dostarlimab for 18 weeks
  • Arm B: Niraparib alone for 3 weeks, followed by Niraparib with Dostarlimab for 15 weeks

Participants with estrogen receptor positive breast cancer will be placed directly into Arm C. There is no randomization for these participants.

  • Arm C: Niraparib with dostarlimab for 18 weeks

It is expected that about 62 people will take part in this research study.

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational drug or drug combination to learn whether the drug combination works in treating a specific disease. "Investigational" means that the study drugs, Niraparib and Dostarlimab, are being studied for use in this setting and the research doctors are trying to learn more about the drug combination-the side effects the combination may cause and if it is effective in treating this type of cancer.

The U.S. Food and Drug Administration (FDA) has not yet approved either of the drugs in this study for your type of cancer. Niraparib has been approved by the FDA for treatment of advanced ovarian cancer in BRCA mutation carriers.

The use of Dostarlimab in this research study is experimental, which means that it is not approved by any regulatory auit is not approved by any regulatory authority, including the FDA, for treatment of breast cancer, or any other disease.

Details
Condition Stage I Breast Cancer, Stage II Breast Cancer, Stage III Breast Cancer, Breast Cancer, HER2-negative Breast Cancer, Germline BRCA1 Gene Mutation, Germline BRCA2 Gene Mutation, Deleterious PALB2 Gene Mutation
Treatment Niraparib, dostarlimab
Clinical Study IdentifierNCT04584255
SponsorDana-Farber Cancer Institute
Last Modified on12 July 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Participants must meet the following criteria on screening examination to be eligible to participate in the study. Laboratory assessments for eligibility must be completed within 14 days prior to the date of registration. Diagnostic imaging, such as MRIs and CT scans, must be performed within 28 days of the planned treatment start
Participants must have histologically or cytologically confirmed invasive breast cancer Stage I to III with primary tumor size at least 1.5 cm defined by physical exam or imaging (whichever is larger). In the case of a multifocal, multicentric, or bilateral disease, the largest lesion must be ≥ 1.5 cm and designated as the "index" lesion for tumor evaluations. Patients with inflammatory breast carcinoma are not eligible
Participants must have documentation of estrogen receptor (ER) and progesterone receptor (PR) testing by IHC according to local institutional guidelines in a CLIA-approved setting. Central confirmation of ER/PR status is not required. All tumors must be HER2 negative
Arms A and B: Target lesion must be ER and PR negative (<10% staining) by local review
Arm C: Target lesion must be ER and/or PR positive (>10% staining) by local review
Participants must have documented HER2-negative invasive tumor according to local
or 1+ by IHC, OR
institutional guidelines in a CLIA-approved setting. Central confirmation of
Lack of gene amplification with HER2/CEP17 ratio < 2 by ISH, OR
HER2 status is not required. HER2 negative is defined as
Copy number < 6 by ISH
Participants with multifocal, multicentric or bilateral disease are eligible if at least one lesion meets criteria for the study. In this circumstance, the investigator must determine which will represent the target lesion to be assessed for response. This should remain consistent throughout the study. The target lesion should be selected on the basis of its size (lesion with the longest diameter) and suitability for accurate repetitive measurements
Participants with an eligible target lesion, and another small HER2+ tumor (for example, < 6 mm), may be eligible for enrollment following discussion and agreement with the overall principal investigator. A formal eligibility exception will not be required in these cases as long as approval by the sponsor-investigator is granted and documented
Participants must have documented germline mutation in BRCA1, BRCA2 or PALB2 that is
deleterious or suspected to be deleterious (known or predicted to be
Breast imaging should include imaging of the ipsilateral axilla. For subjects with a clinically positive axilla by physical examination or imaging, axillary tissue acquisition is not required. For patients with a clinically negative axilla by examination and imaging, tissue acquisition is not required. For equivocal imaging findings, tissue acquisition (a needle aspiration, core biopsy) is required. Sentinel Lymph Node (SLN) biopsy before neoadjuvant therapy is not allowed
detrimental/lead to loss of function). Mutation must be identified through a
ECOG performance status of 0 or 1
CLIA-approved laboratory. Final determination of eligibility for any
Adequate organ and bone marrow function as defined below
discordant results in pathogenicity will be made by the sponsor-investigator
A formal eligibility exception will not be required in these cases as long as
approval by overall study PI is granted and documented
Female or male ≥ 18 years of age
Absolute neutrophil count (ANC) ≥ 1500/mm3
have been amenorrhoeic for <2 years without history of a hysterectomy and oophorectomy with a follicle stimulating hormone value in the postmenopausal range upon screening evaluation
Platelet count ≥ 100,000/mm3
are post-hysterectomy, post-bilateral oophorectomy, or post-tubal ligation. Documented hysterectomy or oophorectomy must be confirmed with medical records of the actual procedure or confirmed by an ultrasound. Tubal ligation must be confirmed with medical records of the actual procedure, otherwise the patient must be willing to use an adequate barrier method throughout the study, starting with the screening visit through 180 days after the last dose of study treatment. See list of acceptable birth control methods. Information must be captured appropriately within the site's source documents. Note: Abstinence is acceptable if this is the established and preferred contraception for the patient
Hemoglobin ≥ 9 g/dl
Total serum bilirubin ≤ 1.5 × institutional upper limit of normal (ULN), (≤2.0 in patients with documented Gilbert's Syndrome)
Female participants must agree to not breastfeed during the study or for 150 days after the last dose of study treatment
AST (SGOT) and ALT (SGPT) ≤ 2.5 × institutional ULN
Participants must agree to not donate blood during the study or for 90 days after the last dose of study treatment
Serum or plasma creatinine ≤ 1.5 × institutional ULN, OR calculated creatinine clearance > 50 mL/min using the Cockcroft-Gault equation
Ability to understand and willingness to sign an informed consent document
International normalized ratio (INR) OR prothrombin time (PT) ≤1.5× ULN. Participants who are receiving anticoagulant therapy are eligible as long as PT or partial thromboplastin (PTT) is within therapeutic range of intended use of anticoagulants. Activated partial thromboplastin time (aPTT) must be ≤1.5× ULN unless patient is receiving anticoagulant therapy as long as PT or PTT is within therapeutic range of intended use of anticoagulants
Ability to swallow and retain oral medication
Premenopausal women must have a negative urine or serum pregnancy test within 7 days
Patients undergoing breast conserving therapy (ie lumpectomy) should not have any contraindications to radiation therapy
of treatment start. Women are considered non-childbearing (by other than
Participants must be willing to undergo the mandatory research biopsy at baseline and after 3 weeks on study treatment. Participants who undergo an attempted research biopsy procedure for the purpose of this protocol and in whom inadequate tissue is obtained are not required to undergo a repeat biopsy in order to continue on the protocol
medical reasons) if they
are ≥45 years of age and without menses for >1 year
Male and female participants of childbearing potential must agree to adhere to
adequate contraception as defined in the protocol for the duration of study
participation and for 150 days after the last dose of study treatment

Exclusion Criteria

Stage IV breast cancer
Concurrent therapy with any other investigational product
Prior treatment for the current breast cancer, including prior chemotherapy, immune therapy, hormonal therapy, radiation, or investigational therapy for this diagnosis
Excisional biopsy of the primary tumor and/or excision of axillary lymph nodes, including SLNB, prior to study treatment
Participants with a history of malignancy are ineligible except in the following
circumstances
Individuals with a history of invasive breast cancer are not eligible unless they have been disease-free for a minimum of three years
Individuals with a malignancy history other than invasive breast cancer are eligible if they have no active malignancy and are deemed by the investigator to be at low risk for recurrence of that malignancy
Individuals with the following cancer history are eligible: adequately treated nonmelanoma skin cancers, curatively treated in situ cancer of the cervix, ductal carcinoma in situ (DCIS) of the breast, stage 1 grade 1 endometrial carcinoma
Other exceptions may exist following agreement with the sponsor-investigator
CT scan pre-medication) are allowed
Patients with autoimmune disease that has required systemic treatment within the past 2 years (i.e. with use of disease-modifying agents, corticosteroids, or immunosuppressive drugs). Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment
Patients with a history of interstitial lung disease or pneumonitis
Patients who have received a live vaccine within 2 weeks prior to the start of study treatment
Patients who have undergone any major surgery within 3 weeks prior to study entry
patients must have recovered to baseline from any effects of any major
surgery
Patients with concurrent HIV infection are eligible provided they meet the following
criteria
No history of AIDS-defining opportunistic infection within 12 months prior to enrollment
Any medication used in an antiretroviral therapy (ART) regimen must have no known interaction with the study agents
Patients with a diagnosis of immunodeficiency, or currently receiving systemic steroid
therapy or any other form of immunosuppressive within 7 days prior to the
Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, recent (within 90 days) myocardial infarction, uncontrolled major seizure disorder, unstable spinal cord compression, superior vena cava syndrome or psychiatric illness/social situations that would limit compliance with study requirements
first dose of study treatment. Use of local corticosteroid injections (e.g
History of allergic reactions attributed to compounds of similar chemical or biologic composition to niraparib, dostarlimab, or their excipients
intraarticular injections), inhaled, intranasal, ophthalmic, and topical
corticosteroids, and subjects requiring corticosteroid pre-medication for
Known history of myelodysplastic syndrome (MDS) or or acute myeloid leukemia (AML)
hypersensitivity reactions (e.g
CD4+ T-cell (CD4+) counts ≥ 350 cells/uL
Patients with active or chronic Hepatitis B or C are eligible provided they meet the
liver function laboratory criteria described in 3.1.10 and cannot be on any
medication with a known interaction with the study agents
Transfusion (platelets or red blood cells) ≤ 4 weeks prior to initiating protocol therapy
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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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