Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)

  • STATUS
    Recruiting
  • participants needed
    20
  • sponsor
    Masonic Cancer Center, University of Minnesota
Updated on 16 August 2022
cyclophosphamide
busulfan
ejection fraction
melphalan
cell transplantation
monocytosis

Summary

The investigators hypothesize that long-term disease-free survival (DFS) in patients with JMML can be achieved with a treatment of busulfan (BU), cyclophosphamide (CY) and melphalan (L-PAM) followed by hematopoietic cell transplantation (HCT).

Description

Prior to transplantation, subjects will receive BUSULFAN via the central venous line, six times a day for four days, CYCLOPHOSPHAMIDE via the central venous line once a day for two days, and MELPHALAN via the central venous line for one day. Busulfan, cyclophosphamide, and melphalan are given to destroy the subject's leukemia. As well, these drugs will destroy the subject's own immune system to help ensure the new bone marrow takes and grows after transplantation.

On the day of transplantation, bone marrow or umbilical cord blood from the donor will arrive to the bone marrow transplant unit and be transfused via venous line. These new cells will replace the subject's bone marrow.

Details
Condition Juvenile Myelomonocytic Leukemia
Treatment Stem Cell Transplant, Stem Cell Transplant, Preparative Regimen
Clinical Study IdentifierNCT00167219
SponsorMasonic Cancer Center, University of Minnesota
Last Modified on16 August 2022

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