Balanced Crystalloid Solutions for Acute Pancreatitis

  • days left to enroll
  • participants needed
  • sponsor
    University Hospital Rijeka
Updated on 29 January 2021


Patients diagnosed with acute pancreatitis regardless of etiology, severity of disease, and prior attacks will be randomized in two groups. The intervention group will receive a balanced crystalloid (Plasmalyte) at a rate of 10 ml/kg during the first 60 min and then continued at 3 ml/kg/h for the next 72 hours. The control group will receive normal saline at the same rate.

Condition Acute Pancreatitis
Treatment Normal saline, Balanced crystalloid solution
Clinical Study IdentifierNCT04688645
SponsorUniversity Hospital Rijeka
Last Modified on29 January 2021


Yes No Not Sure

Inclusion Criteria

patients diagnosed with acute pancreatitis based on the revised Atlanta criteria who present to our hospital within 48 hours of symptoms onset, regardless of etiology, severity of disease, or prior episodes of acute pancreatitis

Exclusion Criteria

chronic pancreatitis
liver cirrhosis (Child-Pugh B and C)
chronic hearth failure (NYHA>II)
acute coronary syndrome
cardiovascular intervention within 60 days before randomization
chronic obstructive pulmonary disease dependent of home oxygenator or acute exacerbation of chronic obstructive pulmonary disease
chronic kidney disease (eGFR <30 ml/min/1.73 m2)
concomitant biliary infection (cholecystitis, cholangitis)
severe autoimmune disease
chronic active infection (TBC, AIDS)
metastatic malignant disease
primary pancreatic neoplasm
patients transferred from other hospitals
pregnancy and ongoing breastfeeding
not willing to participate
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