Ajuvant Chemotherapy and Immunotherapy in Patients With Esophageal Esophageal- Gastric Junction Cancer
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- STATUS
- Recruiting
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- End date
- Dec 31, 2027
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- participants needed
- 200
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- sponsor
- The Second Hospital of Shandong University
Summary
Surgery with or without neoadjuvant therapy is usually used as the treatment for resectable esophageal cancer or esophageal- gastric junction cancer. Patients who have a poor response to neoadjuvant therapy and have an incomplete (R1) resection or have metastatic lymph nodes in the resection specimen (N+) are especially at risk of recurrence, to continue with the chemotherapy radiotherapy is often used in these cases. However, the overall survival is still poor. We designed a prospective randomized controlled tial to study whether immunotherapy could be used with chemotherapy after surgery to improve overall survival. The primary endpoint ofthe study is disease free survival, with secondary endpoints of overall survival, safety and toxicity, and quality of life.
Details
| Condition | Esophageal Diseases, Esophageal Disorders, Esophageal Cancer, Esophageal Cancer, Immunostimulant, Pharmaceutical Adjuvants, head and neck cancer, head and neck cancer, Immunotherapy, Esophageal Carcinoma, Gastroesophageal Cancer, Esophageal Disorders, immunomodulator, immunostimulants, immunomodulators, immunological adjuvant, immunologic adjuvant, esophagus cancer, oesophageal cancer, immunotherapies, cancer of the esophagus, oesophageal carcinoma |
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| Treatment | Immunotherapy, Chemotherapy Drugs, Cancer |
| Clinical Study Identifier | NCT04688801 |
| Sponsor | The Second Hospital of Shandong University |
| Last Modified on | 28 January 2021 |
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