Open-label Study of Neuraminidase Inhibitor Treatment in STEMI Patients
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- STATUS
- Recruiting
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- End date
- Mar 31, 2024
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- participants needed
- 382
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- sponsor
- Tongji Hospital
Summary
Neuraminidase-1 can cause the removal of terminal sialic acid residues from the cell surface or serum sialyloconjugates. The level of Neu5Ac was positively related to the activity of neuraminidase-1. Elevation of Neu5Ac was observed in myocardial ischemia animal model, as well as patients with coronary artery disease. It is interesting to note that Neu5Ac and its regulatory enzyme neuraminidase-1 seem to play a key role in triggering myocardial ischemic injury. Oseltamivir, a structural mimic of sialic acid, was widely used as anti-influenza drug. It suppressed neuraminidase-1 activity in the heart. Targeting neuraminidase-1 may represent a new therapeutic intervention for coronary artery disease. This project seeks to identify whether neuraminidase inhibitor (Oseltamivir) treatment could decrease the myocardial infarct size in STEMI patients and improve clinical outcomes.
Details
| Condition | Myocardial Infarction, Heart Attack (Myocardial Infarction), Heart Attack (Myocardial Infarction), STEMI, ST Elevation Myocardial Infarction |
|---|---|
| Treatment | Oseltamivir phosphate capsules |
| Clinical Study Identifier | NCT04684498 |
| Sponsor | Tongji Hospital |
| Last Modified on | 28 January 2021 |
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