Open-label Study of Neuraminidase Inhibitor Treatment in STEMI Patients

  • End date
    Mar 31, 2024
  • participants needed
  • sponsor
    Tongji Hospital
Updated on 28 January 2021


Neuraminidase-1 can cause the removal of terminal sialic acid residues from the cell surface or serum sialyloconjugates. The level of Neu5Ac was positively related to the activity of neuraminidase-1. Elevation of Neu5Ac was observed in myocardial ischemia animal model, as well as patients with coronary artery disease. It is interesting to note that Neu5Ac and its regulatory enzyme neuraminidase-1 seem to play a key role in triggering myocardial ischemic injury. Oseltamivir, a structural mimic of sialic acid, was widely used as anti-influenza drug. It suppressed neuraminidase-1 activity in the heart. Targeting neuraminidase-1 may represent a new therapeutic intervention for coronary artery disease. This project seeks to identify whether neuraminidase inhibitor (Oseltamivir) treatment could decrease the myocardial infarct size in STEMI patients and improve clinical outcomes.

Condition Myocardial Infarction, Heart Attack (Myocardial Infarction), Heart Attack (Myocardial Infarction), STEMI, ST Elevation Myocardial Infarction
Treatment Oseltamivir phosphate capsules
Clinical Study IdentifierNCT04684498
SponsorTongji Hospital
Last Modified on28 January 2021


Yes No Not Sure

Inclusion Criteria

Between the ages of 18 and 75, regardless of gender
STEMI should be diagnosed by two attending physicians or above, including history, clinical symptoms and signs
Participate voluntarily and sign informed consent, and can be followed up for more than one month

Exclusion Criteria

Allergic to oseltamivir
Creatinine clearance rate less than 60%
Severe liver insufficiency
Female patients who have or plan to become pregnant
Life expectancy less than one year
Patients refused to comply with the requirements of this study
According to the discretion of investigator, the patient was unable to complete the study or comply with the requirements of the study (for administrative or other reasons)
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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