Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT

STATUS

Recruiting
End date

Sep 30, 2024
participants needed

60
sponsor

Washington University School of Medicine

Updated on 15 September 2021

See if I qualify

squamous cell carcinoma

chemotherapy regimen

pet-ct scan

Summary

The investigators propose a longitudinal study evaluating post-treatment changes in patients with squamous cell carcinoma (SCC) of the neck using an innovative optimized diffusion-weighted imaging (DWI) pulse sequence to identify more accurately recurrent tumors as well as early non-responders to therapy.

Details

Condition	Advanced Malignancies, Vulvar Dysplasia and Carcinoma, Squamous Cell Carcinoma, Squamous cell carcinoma, squamous cell cancer, epidermoid carcinoma, Carcinoma
Treatment	Diffusion-weighted imaging magnetic resonance imaging
Clinical Study Identifier	NCT04685798
Sponsor	Washington University School of Medicine
Last Modified on	15 September 2021

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Eligibility		Yes	No	Not Sure
Inclusion Criteria
	Histologically-proven newly diagnosis or recurrence as indicated by tissue diagnosis of T3 or T4 squamous cell carcinoma of the head and neck
	Must have had or be scheduled for standard-of-care surgical resection, radiation, and/or chemo-radiation of the diagnosed squamous cell carcinoma of the head and neck
	At least 18 years of age
	Patient must be able to understand and willing to sign a written informed consent document
Exclusion Criteria
	Contraindications to MRI, including
	MRI-incompatible implantable devices
	severe claustrophobia; and
	Pregnant and/or breastfeeding, with women of childbearing potential having a negative urine or serum pregnancy test
	Lack of standard of care (SOC) PET/CT

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Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT