Optimized Diffusion-Weighted Imaging for the Evaluation of Post-Treatment Squamous Cell Carcinoma in the Neck: Comparative Study With FDG PET/CT

  • End date
    Sep 30, 2024
  • participants needed
  • sponsor
    Washington University School of Medicine
Updated on 14 September 2022
squamous cell carcinoma
chemotherapy regimen
pet-ct scan


The investigators propose a longitudinal study evaluating post-treatment changes in patients with squamous cell carcinoma (SCC) of the neck using an innovative optimized diffusion-weighted imaging (DWI) pulse sequence to identify more accurately recurrent tumors as well as early non-responders to therapy.

Condition Squamous Cell Carcinoma
Treatment Diffusion-weighted imaging magnetic resonance imaging
Clinical Study IdentifierNCT04685798
SponsorWashington University School of Medicine
Last Modified on14 September 2022


Yes No Not Sure

Inclusion Criteria

Histologically-proven newly diagnosis or recurrence as indicated by tissue diagnosis of T3 or T4 squamous cell carcinoma of the head and neck
Must have had or be scheduled for standard-of-care surgical resection, radiation, and/or chemo-radiation of the diagnosed squamous cell carcinoma of the head and neck
At least 18 years of age
Patient must be able to understand and willing to sign a written informed consent document

Exclusion Criteria

Contraindications to MRI, including
MRI-incompatible implantable devices
severe claustrophobia; and
Pregnant and/or breastfeeding, with women of childbearing potential having a negative
Lack of standard of care (SOC) PET/CT
urine or serum pregnancy test
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