Netrin-1 and Placenta Accreta

  • STATUS
    Recruiting
  • End date
    Mar 5, 2023
  • participants needed
    100
  • sponsor
    Assiut University
Updated on 5 June 2022

Summary

Netrin-1 is a secreted protein, which was first identified as a neuronal guidance factor. It is expressed in a multitude of tissues as pancreas, lung, breast, and placenta. Netrin-1 is a multifunctional protein, involved in cell polarity, adhesion, angiogenesis, apoptosis, migration, morphogenesis, and differentiation of various cell types. Most of netrin-1 activity occur through signaling pathways induced by its two main receptors, DCC (deleted in colorectal cancer) and UNC5H (uncoordinated-5 homolog). Its receptors have been linked to the processes of apoptosis and angiogenesis. In absence of netrin-1, DCC and UNC5H receptors lead to apoptosis. In contrary, in presence of netrin-1, receptors transduce molecular cascades leading to proliferation, differentiation and migration of the cells. Netrin-1 has been involved in the pathogenesis of multiple diseases, as diabetes, cardiovascular diseases, and cancer. Serum Netrin-1 levels were high in preeclamptic patients.

Details
Condition Placenta Accreta
Treatment Pregnant women at 28-32 weeks, at delivery
Clinical Study IdentifierNCT04683562
SponsorAssiut University
Last Modified on5 June 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age between 20-40 years
Singleton pregnancy
Women with suspicion of PA by two-dimensional (2D) gray scale imaging and color Doppler flow mapping

Exclusion Criteria

Multiple pregnancy
Fetal anomalies
Preterm premature rupture of membranes, or infection
Any medical disorders, such as thyroid dysfunction, hypertension, and gestational diabetes
Patients with known bleeding disorders or on anticoagulant therapy
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