A Study to Test Whether Different Doses of Alteplase Help People With Severe Breathing Problems Because of COVID-19
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- STATUS
- Recruiting
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- End date
- Aug 15, 2022
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- participants needed
- 270
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- sponsor
- Boehringer Ingelheim
Summary
This is a study in adults with severe breathing problems because of COVID-19. People who are in hospital on breathing support can participate in the study. The purpose of the study is to find out whether a medicine called alteplase helps people get better faster.
The study has 2 parts. In the first part, participants are put into 3 groups by chance. Participants in 2 of the groups get 2 different doses of alteplase, in addition to standard treatment.
Participants in the third group get standard treatment. In the second part of the study, participants are put into 2 groups by chance. One group gets alteplase and standard treatment. The other group gets only standard treatment. Alteplase is given as an infusion into a vein. In both study parts, treatments are given for 5 days. Doctors monitor patients and check whether their breathing problems improve. They compare results between the groups after 1 month.
Participants are in the study for 3 months.
Details
| Condition | Pulmonary Disease, ADULT RESPIRATORY DISTRESS SYNDROME, Acute Respiratory Distress Syndrome (ARDS), Acute Respiratory Distress, Lung Disease, acute respiratory distress syndrome, ards |
|---|---|
| Treatment | Standard of Care, Alteplase |
| Clinical Study Identifier | NCT04640194 |
| Sponsor | Boehringer Ingelheim |
| Last Modified on | 27 October 2021 |
How to participate?
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.
Learn moreIf you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
Learn moreComplete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.
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